Cyclic peptides

2017-08-01T18:00:01+03:00[Europe/Moscow] en true ADH-1, Octreotate, Colistin, Polymyxin B, Argadin, Cyclotide, Yunnanin A, 2,5-Diketopiperazine, Octreotide, Nodularin, Etamycin, Nosiheptide, Bacitracin, Valinomycin, Lanreotide, Nisin, Lugdunin, Ciclosporin, Dactinomycin, Microcystin, Alpha-Amanitin, Daptomycin, Eptifibatide, Valspodar, Pristinamycin, Mycobacillin, Gramicidin S, Cyclotraxin B, Beta-Amanitin, Epsilon-Amanitin, Gamma-Amanitin, Cyclochlorotine, Friulimicin, Cereulide, Hymenistatin, Viscumamide, Merotocin, Phakellistatin 13 flashcards Cyclic peptides
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  • ADH-1
    ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.
  • Octreotate
    Octreotate or octreotide acid is a somatostatin analogue that is closely related to octreotide.
  • Colistin
    Colistin, also known as polymyxin E, is an antibiotic produced by certain strains of the bacteria Paenibacillus polymyxa.
  • Polymyxin B
    Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections.
  • Argadin
    Argadin is a cyclic peptide natural product, investigated for its ability to be a nanomolar inhibitor of Family-18 Chitinases.
  • Cyclotide
    Cyclotides are small disulfide rich peptides isolated from plants.
  • Yunnanin A
    Yunnanin A is a biologically active cyclic peptide.
  • 2,5-Diketopiperazine
    2,5-Diketopiperazine, also known as piperazine-2,5-dione and as the cyclodipeptide cyclo(Gly-Gly), is an organic compound and the smallest cyclic dipeptide that consists of a six-membered ring containing two amide linkages where the two nitrogen atoms and the two carbonyls are at opposite positions in the ring.
  • Octreotide
    Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone.
  • Nodularin
    Nodularin-R is a cyclic nonribosomal peptide produced by the cyanobacterium Nodularia spumigena.
  • Etamycin
    Etamycin is a cyclic peptide antibiotic isolate of marine actinomycete.
  • Nosiheptide
    Nosiheptide is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus.
  • Bacitracin
    Bacitracin is a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, first isolated in 1945.
  • Valinomycin
    Valinomycin is a naturally occurring dodecadepsipeptide used in the transport of potassium and as an antibiotic.
  • Lanreotide
    Lanreotide (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.
  • Nisin
    Nisin is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative.
  • Lugdunin
    Lugdunin is an antibiotic compound, a thiazolidine-containing cyclic peptide.
  • Ciclosporin
    Ciclosporin, also spelled cyclosporine, is an immunosuppressant drug widely used in organ transplantation to prevent rejection.
  • Dactinomycin
    Dactinomycin, also known as actinomycin D, is the most significant member of actinomycines, which are a class of polypeptide antitumor antibiotics isolated from soil bacteria of the genus Streptomyces.
  • Microcystin
    Microcystins (or cyanoginosins) are a class of toxins produced by certain freshwater cyanobacteria; primarily Microcystis aeruginosa but also other Microcystis, as well as members of the Planktothrix, Anabaena, Oscillatoria and Nostoc genera.
  • Alpha-Amanitin
    alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids.
  • Daptomycin
    Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.
  • Eptifibatide
    Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.
  • Valspodar
    Valspodar (PSC833) is an experimental cancer treatment and chemosensitizer drug.
  • Pristinamycin
    Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections.
  • Mycobacillin
    Mycobacillin is an antifungal cyclic peptide.
  • Gramicidin S
    Gramicidin S or Gramicidin Soviet is an antibiotic effective against some Gram positive and Gram negative bacteria as well as some fungi.
  • Cyclotraxin B
    Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective, non-competitive antagonist or negative allosteric modulator of TrkB (IC50  = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF.
  • Beta-Amanitin
    beta-Amanitin or β-amanitin is a cyclic peptide comprising eight amino acids.
  • Epsilon-Amanitin
    epsilon-Amanitin or ε-amanitin is a Cyclic peptide.
  • Gamma-Amanitin
    gamma-Amanitin or γ-amanitin is a Cyclic peptide of eight amino acids.
  • Cyclochlorotine
    Cyclochlorotine (CC) is a mycotoxin produced by the fungus Penicillium islandicum that causes liver damage and has carcinogenic properties.
  • Friulimicin
    Friulimicin B is a lipopeptide antibiotic produced by Actinoplanes friuliensis.
  • Cereulide
    Cereulide is a toxin produced by Bacillus cereus.
  • Hymenistatin
    Hymenistatin is a cyclic peptide isolated from the sea sponge Phakellia fusca.
  • Viscumamide
    Viscumamide is a cyclic peptide isolated from endophytic fungi of mangrove.
  • Merotocin
    Merotocin (INN) (developmental code name FE-202767), also known as carba-1-(4-FBzlGly7)dOT, is a potent (EC50 < 0.1 nM) and highly selective (>1000-fold over the related vasopressin receptors) peptidic agonist of the oxytocin receptor that was derived from oxytocin.
  • Phakellistatin 13
    Phakellistatin 13 is a cytotoxic cycloheptapeptide isolated from marine sponge.