2023-09-22T17:36:28+03:00[Europe/Moscow] en true <p>a</p>, <p>b</p>, <p>c</p>, <p>s. aureus, e.coli, k.pneumoniae </p>, <p>nafcillin, oxacillin, cefazolin </p>, <p>vancomycin </p>, <p>vancomycin, daptomycin, ceftaroline </p>, <p>ceftaroline</p>, <p>Ceftaroline </p>, <p>2-4 weeks </p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>c</p>, <p>a</p>, <p>penicillin, ceftriaxone, gentamicin </p>, <p>ampicillin, gentamicin, ceftriaxone, daptomycin, linezolid </p>, <p>a</p>, <p>e</p>, <p>b</p>, <p>a</p>, <p>b</p>, <p>a</p>, <p>pro: no IV; less chance of infection, con: GI upset</p>, <p>IV = PO</p>, <p>fluoroquinolones; bactrim</p>, <p>a</p>, <p>a</p>, <p>fluconazole </p>, <p>b</p>, <p>echinocandins </p>, <p>amphotericin </p>, <p>d</p>, <p>c</p>, <p>a</p>, <p>b</p>, <p>-cocci suffix </p>, <p>4-6 weeks </p>, <p>a</p>, <p>a,b</p>, <p>c</p> flashcards
CV Infections

CV Infections

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  • a

    Bacteria in the blood.

    a) bacteremia

    b) endocarditis

    c) myocarditis

  • b

    Infection of heart valves.

    a) bacteremia

    b) endocarditis

    c) myocarditis

  • c

    Infection of heart muscle.

    a) bacteremia

    b) endocarditis

    c) myocarditis

  • s. aureus, e.coli, k.pneumoniae

    What are the most common pathogens involved in CV infections? (3)

  • nafcillin, oxacillin, cefazolin

    What are the drugs of choice for MSSA Bacteriemia? (3)

  • vancomycin

    ________ cannot be used for MSSA bacteremia.

  • vancomycin, daptomycin, ceftaroline

    What are the drugs of choice for MRSA Bacteremia? (3)

  • ceftaroline

    _________ is the only beta-lactam with MRSA coverage.

  • Ceftaroline

    -binds to PBPs--> blocks peptidoglycan synthesis--> inhibits cell wall synthesis

  • 2-4 weeks

    How long is treatment with Ceftaroline for MRSA Bacteremia?

  • a

    Which requires NO renal dose adjustments?

    a) Anti-staph pens

    b) Vancomycin

    c) Daptomycin

    d) Ceftaroline

  • b

    Which has very patient-specific dosing?

    a) Anti-staph pens

    b) Vancomycin

    c) Daptomycin

    d) Ceftaroline

  • c

    Which can increase CPK and lead to myopathy?

    a) Anti-staph pens

    b) Vancomycin

    c) Daptomycin

    d) Ceftaroline

  • c

    Which HAS to be used in synergy?

    a) penicillin

    b) ceftriaxone

    c) gentamicin

  • a

    Which is the DOC for streptococci?

    a) penicillin

    b) ceftriaxone

    c) gentamicin

  • penicillin, ceftriaxone, gentamicin

    What drugs do we use to treat Streptococcal Bacteremia? (3)

  • ampicillin, gentamicin, ceftriaxone, daptomycin, linezolid

    What drugs do we use to treat Enterococcal Bacteremia? (5)

  • a

    Which is the DOC for E.faecalis ?

    a) ampicillin

    b) gentamicin

    c) ceftriaxone

    d) daptomycin

    e) linezolid

  • e

    Which can cause thrombocytopenia?

    a) ampicillin

    b) gentamicin

    c) ceftriaxone

    d) daptomycin

    e) linezolid

  • b

    Which combination is safer?

    a) ampicillin + gentamicin

    b) ampicillin + ceftriaxone

  • a

    Which combination can be used once-daily?

    a) ampicillin + gentamicin

    b) ampicillin + ceftriaxone

  • b

    Which combo has the higher risk for C.diff ?

    a) ampicillin + gentamicin

    b) ampicillin + ceftriaxone

  • a

    Which combo has a more narrow-spectrum?

    a) ampicillin + gentamicin

    b) ampicillin + ceftriaxone

  • pro: no IV; less chance of infection, con: GI upset

    What are the Pros/Cons of PO treatment ?

  • IV = PO

    If drug bioavailability is high,

  • fluoroquinolones; bactrim

    What are the best ab's at treating Gm (-) bacteremia? (2)

  • a

    Which has IV & PO options?

    a) fluconazole

    b) echinocandins

    c) amphotericin

  • a

    Which can cause QTc prolongation?

    a) fluconazole

    b) echinocandins

    c) amphotericin

  • fluconazole

    interferes with fungal P450 activity---> decreases ergosterol synthesis

    and inhibits cell membrane formation

  • b

    Which DOESN'T require a loading dose?

    a) caspofungin

    b) micafungin

    c) anidulafungin

  • echinocandins

    inhibits 1,3-beta-D-glucan synthase---> decreases glucan content--->

    causes osmotic instability and cell lysis

  • amphotericin

    binds to ergosterol--> causing cell membrane impermeability-->> causes

    leakage of cell components--> leads to cell death

  • d

    Which is the conventional form?

    a) Abelcet

    b) AmBisome

    c) Amphotec

    d) Ampho B deoxycholate

  • c

    Which is the Cholesterly sulfate complex?

    a) Abelcet

    b) AmBisome

    c) Amphotec

    d) Ampho B deoxycholate

  • a

    Which is the lipid complex?

    a) Abelcet

    b) AmBisome

    c) Amphotec

    d) Ampho B deoxycholate

  • b

    Which is the liposomal form?

    a) Abelcet

    b) AmBisome

    c) Amphotec

    d) Ampho B deoxycholate

  • -cocci suffix

    Which pathogens usually cause endocarditis?

  • 4-6 weeks

    How long is endocarditis treatment?

  • a

    Prosthetic valve + streptococci= add ______

    a) gentamicn

    b) rifampin

    c) no difference in treatment

  • a,b

    Prosthetic valve + staphylococci = add _____

    a) gentamicn

    b) rifampin

    c) no difference in treatment

  • c

    Prosthetic valve + enterococci = add ____

    a) gentamicn

    b) rifampin

    c) no difference in treatment