2023-08-03T19:15:26+03:00[Europe/Moscow] en true <p>fibrin</p>, <p>tissue factor </p>, <p>3, 7, 10</p>, <p>12, 11, 9+8, 10+5</p>, <p>antithrombin</p>, <p>5,7,8,11, 13</p>, <p>fibrinogen </p>, <p>10 </p>, <p>plasmin </p>, <p>c</p>, <p>a</p>, <p>b</p>, <p>endothelial cells release tissue factor; tissue factor activates 7 into 7a; 7a activates 10 into 10a to produce thrombin</p>, <p>10a activates 12--11--9 &amp; 8--10 all into active forms; produces the bulk of thrombin </p>, <p>Factor 13</p> flashcards
Clotting Cascade

Clotting Cascade

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  • fibrin

    an insoluble protein formed during the clotting of blood. It forms a fibrous mesh that impedes the flow of blood

  • tissue factor

    -released after injury to blood vessel and begins the clotting cascade

  • 3, 7, 10

    Which clotting factors are involved in the Extrinsic Pathway?

  • 12, 11, 9+8, 10+5

    Which clotting factors are involved in the Intrinsic Pathway?

  • antithrombin

    -decreases thrombin and the amount of Activated Clotting factor 10.

  • 5,7,8,11, 13

    Which clotting factors does thrombin activate?

  • fibrinogen

    -the inactive form of the protein that circulates in the bloodstream and is responsible for sticking platelets together to help form the platelet plug

  • 10

    Which clotting factor activates thrombin?

  • plasmin

    -an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.

  • c

    Hemophilia A is a deficiency in clotting factor

    a) 9

    b) 11

    c) 8

  • a

    Hemophilia B is a deficiency in clotting factor

    a) 9

    b) 11

    c) 8

  • b

    Hemophilia C is a deficiency in clotting factor

    a) 9

    b) 11

    c) 8

  • endothelial cells release tissue factor; tissue factor activates 7 into 7a; 7a activates 10 into 10a to produce thrombin

    What is the role of the extrinsic pathway?

  • 10a activates 12--11--9 & 8--10 all into active forms; produces the bulk of thrombin

    What is the role of the intrinsic pathway?

  • Factor 13

    -an enzyme of the blood coagulation system that crosslinks fibrin.