fibrin
an insoluble protein formed during the clotting of blood. It forms a fibrous mesh that impedes the flow of blood
tissue factor
-released after injury to blood vessel and begins the clotting cascade
3, 7, 10
Which clotting factors are involved in the Extrinsic Pathway?
12, 11, 9+8, 10+5
Which clotting factors are involved in the Intrinsic Pathway?
antithrombin
-decreases thrombin and the amount of Activated Clotting factor 10.
5,7,8,11, 13
Which clotting factors does thrombin activate?
fibrinogen
-the inactive form of the protein that circulates in the bloodstream and is responsible for sticking platelets together to help form the platelet plug
10
Which clotting factor activates thrombin?
plasmin
-an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.
c
Hemophilia A is a deficiency in clotting factor
a) 9
b) 11
c) 8
a
Hemophilia B is a deficiency in clotting factor
a) 9
b) 11
c) 8
b
Hemophilia C is a deficiency in clotting factor
a) 9
b) 11
c) 8
endothelial cells release tissue factor; tissue factor activates 7 into 7a; 7a activates 10 into 10a to produce thrombin
What is the role of the extrinsic pathway?
10a activates 12--11--9 & 8--10 all into active forms; produces the bulk of thrombin
What is the role of the intrinsic pathway?
Factor 13
-an enzyme of the blood coagulation system that crosslinks fibrin.