2023-11-02T02:15:21+03:00[Europe/Moscow] en true <p>ACEi/ARB, SGLT2, MRA, Metformin, GLP1 receptor agonists</p>, <p>lisinopril </p>, <p>candesartan, olmesartan </p>, <p>flozin suffix</p>, <p>reduce glucose/sodium reabsorption in proximal tubule; decreasing glomerular hyperfiltration/hypertension </p>, <p>increased risk of genitourinary infection, ketoacidosis, lower limb amputation </p>, <p>gluconolactone; OGT</p>, <p>water, sugar, electrolytes</p>, <p>finerenone</p>, <p>blocks receptor-mediated sodium reabsorption/overactivation; reduces fibrosis and inflammation </p>, <p>bulky non-steroid; dihydropyridine </p>, <p>glutide suffix </p>, <p>analog of human GLP1 receptor; balances insulin/glucagon secretion; decreases food intake </p>, <p>peptides; dipeptidyl peptidase 4</p>, <p>antibody development/injection site reaction, hypoglycemia, tachycardia, headache </p>, <p>biguanide </p>, <p>inhibits mitochondrial complex 1; increases AMPK to decrease hepatic glucose production and improve glucose utilization &amp; insulin sensitivity </p>, <p>c</p>, <p>d</p>, <p>a</p>, <p>chlorthalidone </p>, <p>inhibit VGCC in glomerulus/renal tubules suppressing glomerular hypertrophy and salt accumulation in the kidneys </p> flashcards
CKD Pharmacology

CKD Pharmacology

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  • ACEi/ARB, SGLT2, MRA, Metformin, GLP1 receptor agonists

    What are the drug classes for treating CKD? (5)

  • lisinopril

    Which ACEi is NOT a prodrug?

  • candesartan, olmesartan

    Which ARB's ARE prodrugs? (2)

  • flozin suffix

    What are the SGLT2 inhibitors?

  • reduce glucose/sodium reabsorption in proximal tubule; decreasing glomerular hyperfiltration/hypertension

    SGLT2 MOA?

  • increased risk of genitourinary infection, ketoacidosis, lower limb amputation

    What are AE's associated with SGLT2 inhibitors? (3)

  • gluconolactone; OGT

    All SGLT2 inhibitors contain a _________ and are metabolized by ______.

  • water, sugar, electrolytes

    What must be monitored when a patient is on an SGLT2 inhibitor? (3)

  • finerenone

    What is our Non-Steroidal MRA?

  • blocks receptor-mediated sodium reabsorption/overactivation; reduces fibrosis and inflammation

    Finerenone MOA?

  • bulky non-steroid; dihydropyridine

    Finerenone contains a ______ group otherwise known as ______.

  • glutide suffix

    What are the GLP1 Receptor agonists?

  • analog of human GLP1 receptor; balances insulin/glucagon secretion; decreases food intake

    GLP1 Receptor agonists MOA?

  • peptides; dipeptidyl peptidase 4

    GLP1 agonists are ________ and metabolized by _________.

  • antibody development/injection site reaction, hypoglycemia, tachycardia, headache

    What are AE's associated with GLP1 Agonists? (4)

  • biguanide

    Metformin contains a _______ group.

  • inhibits mitochondrial complex 1; increases AMPK to decrease hepatic glucose production and improve glucose utilization & insulin sensitivity

    Metformin MOA?

  • c

    Which has a BBW for lactic acidosis?

    a) ACEi/ARB

    b) SGLT2 inhibitors

    c) Metformin

    d) GLP1 agonists

    e) Finerenone

  • d

    Which has a BBW for thyroid C-cell tumors?

    a) ACEi/ARB

    b) SGLT2 inhibitors

    c) Metformin

    d) GLP1 agonists

    e) Finerenone

  • a

    Which has a BBW for fetal toxicity?

    a) ACEi/ARB

    b) SGLT2 inhibitors

    c) Metformin

    d) GLP1 agonists

    e) Finerenone

  • chlorthalidone

    Which thiazide diuretic has utility in CKD?

  • inhibit VGCC in glomerulus/renal tubules suppressing glomerular hypertrophy and salt accumulation in the kidneys

    Non-DHP CCBs MOA?