ACEi/ARB, SGLT2, MRA, Metformin, GLP1 receptor agonists
What are the drug classes for treating CKD? (5)
lisinopril
Which ACEi is NOT a prodrug?
candesartan, olmesartan
Which ARB's ARE prodrugs? (2)
flozin suffix
What are the SGLT2 inhibitors?
reduce glucose/sodium reabsorption in proximal tubule; decreasing glomerular hyperfiltration/hypertension
SGLT2 MOA?
increased risk of genitourinary infection, ketoacidosis, lower limb amputation
What are AE's associated with SGLT2 inhibitors? (3)
gluconolactone; OGT
All SGLT2 inhibitors contain a _________ and are metabolized by ______.
water, sugar, electrolytes
What must be monitored when a patient is on an SGLT2 inhibitor? (3)
finerenone
What is our Non-Steroidal MRA?
blocks receptor-mediated sodium reabsorption/overactivation; reduces fibrosis and inflammation
Finerenone MOA?
bulky non-steroid; dihydropyridine
Finerenone contains a ______ group otherwise known as ______.
glutide suffix
What are the GLP1 Receptor agonists?
analog of human GLP1 receptor; balances insulin/glucagon secretion; decreases food intake
GLP1 Receptor agonists MOA?
peptides; dipeptidyl peptidase 4
GLP1 agonists are ________ and metabolized by _________.
antibody development/injection site reaction, hypoglycemia, tachycardia, headache
What are AE's associated with GLP1 Agonists? (4)
biguanide
Metformin contains a _______ group.
inhibits mitochondrial complex 1; increases AMPK to decrease hepatic glucose production and improve glucose utilization & insulin sensitivity
Metformin MOA?
c
Which has a BBW for lactic acidosis?
a) ACEi/ARB
b) SGLT2 inhibitors
c) Metformin
d) GLP1 agonists
e) Finerenone
d
Which has a BBW for thyroid C-cell tumors?
a) ACEi/ARB
b) SGLT2 inhibitors
c) Metformin
d) GLP1 agonists
e) Finerenone
a
Which has a BBW for fetal toxicity?
a) ACEi/ARB
b) SGLT2 inhibitors
c) Metformin
d) GLP1 agonists
e) Finerenone
chlorthalidone
Which thiazide diuretic has utility in CKD?
inhibit VGCC in glomerulus/renal tubules suppressing glomerular hypertrophy and salt accumulation in the kidneys
Non-DHP CCBs MOA?