2023-03-18T06:13:41+03:00[Europe/Moscow] en true <p>inhibits protein synthesis by binding to 50s &amp; inhibiting peptidyl transferase</p>, <p>static/cidal; gm+; gm- anaerobes </p>, <p>staph</p>, <p>macrolides; clindamycin</p>, <p>glucuronic acid conjugation</p>, <p>myelosuppresion, irreversible aplastic anemia, gray syndrome</p>, <p>gray syndrome </p>, <p>retapamulin, lefamulin</p>, <p>topical gel</p>, <p>iv/ po</p>, <p>iv</p>, <p>semi-synthetic </p>, <p>impetigo from staph aureus &amp; strep pyogenes</p>, <p>MRSA</p>, <p>adults with CABP</p>, <p>those metabolized by CYP3A4</p>, <p>diarrhea, N&amp;V, hepatic enzyme elevation</p>, <p>QT prolongation, embryo-fetal toxicity, c.diff</p>, <p>ribosomal protection</p> flashcards
Chloramphenicol/ Pleuromutilins

Chloramphenicol/ Pleuromutilins

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  • inhibits protein synthesis by binding to 50s & inhibiting peptidyl transferase

    What is the MOA for chloramphenicol & Pleuromutilins?

  • static/cidal; gm+; gm- anaerobes

    What is the spectrum for Chloramphenicol?

  • staph

    Which bacteria is chloramphenicol NOT effective against?

  • macrolides; clindamycin

    Which drugs can cause drug interactions with Chloramphenicol?

  • glucuronic acid conjugation

    How is Chloramphenicol metabolized?

  • myelosuppresion, irreversible aplastic anemia, gray syndrome

    What are toxic side effects associated with Chloramphenicol?

  • gray syndrome

    -most common in neonates who receive chloramphenicol; caused by their inability to metabolized the drug due to their low levels of GA metabolizing enzymes.

    -causes circulatory based motor collapse, vomiting, shock

  • retapamulin, lefamulin

    What are our pleuromutilins?

  • topical gel

    What is the dosage form of retapamulin?

  • iv/ po

    What is the dosage form of Lefamulin?

  • iv

    What is the dosage form of chloramphenicol?

  • semi-synthetic

    Pleuromutilins are considered _________ antibiotics.

  • impetigo from staph aureus & strep pyogenes

    Retapamulin tx?

  • MRSA

    Retapamulin cannot treat ______ infections.

  • adults with CABP

    Lefamulin tx?

  • those metabolized by CYP3A4

    What drugs should be avoided when taking Lefamulin?

  • diarrhea, N&V, hepatic enzyme elevation

    Tablet se's in Lefamulin?

  • QT prolongation, embryo-fetal toxicity, c.diff

    Toxic concerns with Lefamulin?

  • ribosomal protection

    How do bacteria resist Lefamulin?