inhibits protein synthesis by binding to 50s & inhibiting peptidyl transferase
What is the MOA for chloramphenicol & Pleuromutilins?
static/cidal; gm+; gm- anaerobes
What is the spectrum for Chloramphenicol?
staph
Which bacteria is chloramphenicol NOT effective against?
macrolides; clindamycin
Which drugs can cause drug interactions with Chloramphenicol?
glucuronic acid conjugation
How is Chloramphenicol metabolized?
myelosuppresion, irreversible aplastic anemia, gray syndrome
What are toxic side effects associated with Chloramphenicol?
gray syndrome
-most common in neonates who receive chloramphenicol; caused by their inability to metabolized the drug due to their low levels of GA metabolizing enzymes.
-causes circulatory based motor collapse, vomiting, shock
retapamulin, lefamulin
What are our pleuromutilins?
topical gel
What is the dosage form of retapamulin?
iv/ po
What is the dosage form of Lefamulin?
iv
What is the dosage form of chloramphenicol?
semi-synthetic
Pleuromutilins are considered _________ antibiotics.
impetigo from staph aureus & strep pyogenes
Retapamulin tx?
MRSA
Retapamulin cannot treat ______ infections.
adults with CABP
Lefamulin tx?
those metabolized by CYP3A4
What drugs should be avoided when taking Lefamulin?
diarrhea, N&V, hepatic enzyme elevation
Tablet se's in Lefamulin?
QT prolongation, embryo-fetal toxicity, c.diff
Toxic concerns with Lefamulin?
ribosomal protection
How do bacteria resist Lefamulin?