2022-10-31T22:53:50+03:00[Europe/Moscow] en true <p>Ischemia </p>, <p>Infarction</p>, <p>Primary hypercholesterolemia </p>, <p>Secondary hypercholesterolemia </p>, <p>statins, resins, cholesterol inhibitors, niacin, fibrates</p>, <p>fatty streaks, fibrous atheromatous plaques, complicated lesions</p>, <p>Fatty streaks</p>, <p>Fibrous atheromatous plaques</p>, <p>Complicated lesions</p>, <p>damage; inflammatory response</p>, <p>ingest; large foam cells</p>, <p>tunica media; tunica intima; cytokines</p>, <p>rate-limiting of mevalonate </p>, <p>raynaud's disease</p>, <p>raynaud's phenomenon</p>, <p>etiology of raynauds</p>, <p>pathogenesis of raynaud disease</p>, <p>pathogenesis of raynaud phenomenon</p>, <p>etiology and pathogensis of venous thrombosis</p>, <p>compression, heparin, warfarin</p>, <p>beta-adrenergic antagonists, surgical grafts</p> flashcards
Ch.30 - Disorders of Blood Flow in Systemic Circulation

Ch.30 - Disorders of Blood Flow in Systemic Circulation

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  • Ischemia

    -reduction in blood flow to levels insufficient to meet tissue oxygen demands

  • Infarction

    -ischemic necrosis in an organ

  • Primary hypercholesterolemia

    -familial hypercholesterolemia; LDL receptor deficiency/ dysfunction with marked elevated levels

  • Secondary hypercholesterolemia

    -obesity, high calorie intake, diabetes mellitus

    -LDL levels exceed receptor efficiency

  • statins, resins, cholesterol inhibitors, niacin, fibrates

    Major medications for hyperlipidemia?

  • fatty streaks, fibrous atheromatous plaques, complicated lesions

    What are the 3 pathogenic results of artherosclerosis?

  • Fatty streaks

    thin, fatty, intimal plaques composed of macrophages and smooth muscle cells with lipids to form foam cells; attracts monocytes

  • Fibrous atheromatous plaques

    -large, fibrous plaques with inflammation that may occlude vessel causing thrombus formation

  • Complicated lesions

    -contain hemorrhage, ulceration, scar tissue

  • damage; inflammatory response

    Atherosclerosis will eventually _________ endothelium; resulting in ________

  • ingest; large foam cells

    Monocytes _____________ oxidized LDL; turn into _________

  • tunica media; tunica intima; cytokines

    Smooth muscle proliferation and migration from _________ to the __________ in response to ________ secreted by damaged endothelial cells.

  • rate-limiting of mevalonate

    HMG CoA Reductase Inhibitors (statins) inhibit what step?

  • raynaud's disease

    primary type; no known cause

  • raynaud's phenomenon

    secondary type; associated with other disease states or known causes of vasospasms

  • etiology of raynauds

    -sympathetic vasoconstriction causing vasospams resulting in ischemia

  • pathogenesis of raynaud disease

    Exposure to cold, stress, strong emotion

  • pathogenesis of raynaud phenomenon

    trauma, occupational traumas, collagen diseases, neruological disorders, hot-cold exposures

  • etiology and pathogensis of venous thrombosis

    stasis of blood, increased coagulation, vessel wall injury, spinal cord injury, impaired cardiac function

  • compression, heparin, warfarin

    treatment for venous thrombosis

  • beta-adrenergic antagonists, surgical grafts

    treatment for aneurysms