Flashcards: Ch.30 - Disorders of Blood Flow in Systemic Circulation

-reduction in blood flow to levels insufficient to meet tissue oxygen demands

-ischemic necrosis in an organ

-familial hypercholesterolemia; LDL receptor deficiency/ dysfunction with marked elevated levels

-obesity, high calorie intake, diabetes mellitus

-LDL levels exceed receptor efficiency

Major medications for hyperlipidemia?

What are the 3 pathogenic results of artherosclerosis?

thin, fatty, intimal plaques composed of macrophages and smooth muscle cells with lipids to form foam cells; attracts monocytes

-large, fibrous plaques with inflammation that may occlude vessel causing thrombus formation

-contain hemorrhage, ulceration, scar tissue

Atherosclerosis will eventually _________ endothelium; resulting in ________

Monocytes _____________ oxidized LDL; turn into _________

Smooth muscle proliferation and migration from _________ to the __________ in response to ________ secreted by damaged endothelial cells.

HMG CoA Reductase Inhibitors (statins) inhibit what step?

primary type; no known cause

secondary type; associated with other disease states or known causes of vasospasms

-sympathetic vasoconstriction causing vasospams resulting in ischemia

Exposure to cold, stress, strong emotion

trauma, occupational traumas, collagen diseases, neruological disorders, hot-cold exposures

stasis of blood, increased coagulation, vessel wall injury, spinal cord injury, impaired cardiac function

treatment for venous thrombosis

treatment for aneurysms