2023-02-08T20:11:48+03:00[Europe/Moscow] en true <p>cefaclor, cefprozil, cefuroxime axetil</p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>c</p>, <p>h.flu</p>, <p>rash, serum sickness</p>, <p>northeast &amp; upper midwest</p>, <p>cefuroxime, cefotetan, cefoxitin, metronidazole</p>, <p>metronidazole</p>, <p>a</p>, <p>a</p>, <p>b,c</p>, <p>increased bleeding, eosinophilia, disulfiram-like activity</p>, <p>b,c</p>, <p>increased activity against anaerobes; increased stability to ceph'ases</p>, <p>N-MTT</p>, <p>oral, parenteral, enema, suppositories, vaginal gels</p>, <p>synthetic</p>, <p>1st line; anaerboic</p>, <p>a</p>, <p>d</p>, <p>n&amp;v, disulfiram-like activity, furry tongue, seizure</p>, <p>alcohol; 48 hours</p>, <p>bulky group that blocks b-lactamases &amp; ceph'ases</p>, <p>cefaclor; cefprozil</p>, <p>no axetil side chain</p> flashcards
Cephalosporins 2nd Gen

Cephalosporins 2nd Gen

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  • cefaclor, cefprozil, cefuroxime axetil

    What are our Oral 2nd generation Cephs? (3)

  • a

    Which 2nd generation Ceph has an ampicillin side chain?

    a) cefaclor

    b) cefprozil

    c) cefuroxime axetil

  • b

    Which 2nd generation Ceph has an amoxicillin side chain?

    a) cefaclor

    b) cefprozil

    c) cefuroxime axetil

  • c

    Which 2nd generation Ceph is a prodrug?

    a) cefaclor

    b) cefprozil

    c) cefuroxime axetil

  • c

    Which 2nd generation Ceph is a 1st line agent for Lyme disease?

    a) cefaclor

    b) cefprozil

    c) cefuroxime axetil

  • h.flu

    What gm- bacteria is Cefaclor active against?

  • rash, serum sickness

    What are the side effects associated with Cefaclor?

  • northeast & upper midwest

    Where are 90% of Lyme disease cases reported in the United States?

  • cefuroxime, cefotetan, cefoxitin, metronidazole

    What are our Parenteral 2nd generation Cephs? (4)

  • metronidazole

    Which 2nd generation Ceph is available orally & parenterally?

  • a

    Which Parenteral Ceph is used to treat more severe Gm- infections?

    a) cefuroxime

    b) cefotetan

    c) cefoxitin

  • a

    Which Parenteral Ceph is used as a 1st line treatment for Lyme disease?

    a) cefuroxime

    b) cefotetan

    c) cefoxitin

  • b,c

    Which Parenteral Ceph has activity against some Gm (-) anaerobes?

    a) cefuroxime

    b) cefotetan

    c) cefoxitin

  • increased bleeding, eosinophilia, disulfiram-like activity

    What are side effects associated with Cefotetan?

  • b,c

    Which Paraenteral Ceph has a cephamycin structure?

    a) cefuroxime

    b) cefotetan

    c) cefoxitin

  • increased activity against anaerobes; increased stability to ceph'ases

    What is the function of cephamycin?

  • N-MTT

    What is the functional group that is responsible for SE in Cefotetan?

  • oral, parenteral, enema, suppositories, vaginal gels

    What are the different dosage forms for metronidazole?

  • synthetic

    Metronidazole is a _______ compound.

  • 1st line; anaerboic

    Metronidazole is a ________ treatment for _________ infections.

  • a

    Which 2nd generation Ceph has drug interactions with warfarin & antabuse?

    a) metronidazole

    b) cefoxitin

    c) cefuroxime

    d) cefprozil

  • d

    Which 2nd gen Ceph is contraindicated in patients who are pregnant, breast-feeding or have seizure disorders?

    a) cefuroxime

    b) cefotetan

    c) cefoxitin

    d) metronidazole

  • n&v, disulfiram-like activity, furry tongue, seizure

    SE associated with Metronidazole?

  • alcohol; 48 hours

    What substance should be avoiding while taking Metronidazole & for how long?

  • bulky group that blocks b-lactamases & ceph'ases

    What is the purpose of the 'oxime' functional group?

  • cefaclor; cefprozil

    ________ has a Cl- group attached to it to improve its oral bioavailability; while ______ has a lipophilic vinyl group to improve its GI absorption.

  • no axetil side chain

    How was the parenteral form of Cefuroxime made more H20 soluble?