cefaclor, cefprozil, cefuroxime axetil
What are our Oral 2nd generation Cephs? (3)
a
Which 2nd generation Ceph has an ampicillin side chain?
a) cefaclor
b) cefprozil
c) cefuroxime axetil
b
Which 2nd generation Ceph has an amoxicillin side chain?
a) cefaclor
b) cefprozil
c) cefuroxime axetil
c
Which 2nd generation Ceph is a prodrug?
a) cefaclor
b) cefprozil
c) cefuroxime axetil
c
Which 2nd generation Ceph is a 1st line agent for Lyme disease?
a) cefaclor
b) cefprozil
c) cefuroxime axetil
h.flu
What gm- bacteria is Cefaclor active against?
rash, serum sickness
What are the side effects associated with Cefaclor?
northeast & upper midwest
Where are 90% of Lyme disease cases reported in the United States?
cefuroxime, cefotetan, cefoxitin, metronidazole
What are our Parenteral 2nd generation Cephs? (4)
metronidazole
Which 2nd generation Ceph is available orally & parenterally?
a
Which Parenteral Ceph is used to treat more severe Gm- infections?
a) cefuroxime
b) cefotetan
c) cefoxitin
a
Which Parenteral Ceph is used as a 1st line treatment for Lyme disease?
a) cefuroxime
b) cefotetan
c) cefoxitin
b,c
Which Parenteral Ceph has activity against some Gm (-) anaerobes?
a) cefuroxime
b) cefotetan
c) cefoxitin
increased bleeding, eosinophilia, disulfiram-like activity
What are side effects associated with Cefotetan?
b,c
Which Paraenteral Ceph has a cephamycin structure?
a) cefuroxime
b) cefotetan
c) cefoxitin
increased activity against anaerobes; increased stability to ceph'ases
What is the function of cephamycin?
N-MTT
What is the functional group that is responsible for SE in Cefotetan?
oral, parenteral, enema, suppositories, vaginal gels
What are the different dosage forms for metronidazole?
synthetic
Metronidazole is a _______ compound.
1st line; anaerboic
Metronidazole is a ________ treatment for _________ infections.
a
Which 2nd generation Ceph has drug interactions with warfarin & antabuse?
a) metronidazole
b) cefoxitin
c) cefuroxime
d) cefprozil
d
Which 2nd gen Ceph is contraindicated in patients who are pregnant, breast-feeding or have seizure disorders?
a) cefuroxime
b) cefotetan
c) cefoxitin
d) metronidazole
n&v, disulfiram-like activity, furry tongue, seizure
SE associated with Metronidazole?
alcohol; 48 hours
What substance should be avoiding while taking Metronidazole & for how long?
bulky group that blocks b-lactamases & ceph'ases
What is the purpose of the 'oxime' functional group?
cefaclor; cefprozil
________ has a Cl- group attached to it to improve its oral bioavailability; while ______ has a lipophilic vinyl group to improve its GI absorption.
no axetil side chain
How was the parenteral form of Cefuroxime made more H20 soluble?