2019-10-29T17:18:20+03:00[Europe/Moscow] en true Limiting Barrier, Carbs bound to proteins, Carbs bound to lipids, What is the hydrophobic part of the amphipathic lipid?, What is the hydrophilic part of the amphiphatic lipids in the membrane?, What are the major phospholipids found in the cell membrane?, Is the plasma membrane symmetrical? , What movements are common or uncommon?, Which leaflet do you find glycolipids?, Where do you find cholesterol?, Contain transmembrane domains with hydrophobic amino acids side chains interacting with hydrophobic lipids to seal the membrane, ex) channels, transporters, and receptors, Bound through weak electrostatic interactions between polar head groups or with integral proteins, Hydrophilic carbohydrate layer, RBC recognition, What maintains membrane fluidity?, What prevents densely packed membrane?, What are examples of simple diffusion molecules?, What are examples of simple diffusion mediated channels?, What are the tenants of facilitated diffusion?, What are examples of facilitated transport?, Active transport, Transports out of the cell, Vesicular transport into the cell, What are the two types of endocytosis?, What kind of membrane is around lysosomes?, What kind of membrane surrounds the mitochondria?, What provides the scaffolding or framework of the cell?, What makes up the cytoskeleton?, Mutations in the gene encoding the fibroblast growth factor receptor 3, *Mutations in the gene encoding the LDL receptor, *Mutations in the gene encoding the CFTR protein, a Cl- transporter, mutations in the genes encoding ion channels in the heart, Mutations in the gene encoding a copper dependent ATPase, * mutations in the genes encoding spectrin or other structural proteins in the red cell membrane flashcards
Cell Membrane questions

Cell Membrane questions

  • Limiting Barrier
    Plasma membrane that separates the internal contents of the cell from external materials
  • Carbs bound to proteins
    Glycoproteins
  • Carbs bound to lipids
    Glycolipids
  • What is the hydrophobic part of the amphipathic lipid?
    FA chain
  • What is the hydrophilic part of the amphiphatic lipids in the membrane?
    Polar head group, negative phosphate
  • What are the major phospholipids found in the cell membrane?
    Phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol
  • Is the plasma membrane symmetrical? 
    No, asymmetry from PC and sphingomyelin in outer leaflet and PS and PE in inner leaflet
  • What movements are common or uncommon?
    Lateral movement is common, flip-flop is uncommon
  • Which leaflet do you find glycolipids?
    Outer leaflet
  • Where do you find cholesterol?
    Interspersed between phospholipids
  • Contain transmembrane domains with hydrophobic amino acids side chains interacting with hydrophobic lipids to seal the membrane, ex) channels, transporters, and receptors
    Integral proteins
  • Bound through weak electrostatic interactions between polar head groups or with integral proteins
    Peripheral proteins
  • Hydrophilic carbohydrate layer
    Glycocalyx
  • RBC recognition
    Specific carb chains on glycolipids serve as cell recognition molecules
  • What maintains membrane fluidity?
    Cholesterol
  • What prevents densely packed membrane?
    Unsaturated FAs and cholesterol
  • What are examples of simple diffusion molecules?
    H2O, O2, CO2, urea
  • What are examples of simple diffusion mediated channels?
    Water filled pore. 
  • What are the tenants of facilitated diffusion?
    Can transport protein, solute interacts with transport protein, process is still passive, no energy required, flow down conc gradient
  • What are examples of facilitated transport?
    GLUT - glucose transporter
  • Active transport
    Requires input of energy, ATP or ion gradient, solute may move against conc gradient
  • Transports out of the cell
    Exocytosis
  • Vesicular transport into the cell
    Endocytosis
  • What are the two types of endocytosis?
    Receptor mediated endocytosis & phagocytosis and autophagy
  • What kind of membrane is around lysosomes?
    Single membrane
  • What kind of membrane surrounds the mitochondria?
    Double membrane
  • What provides the scaffolding or framework of the cell?
    the cytoskeleton
  • What makes up the cytoskeleton?
    microtubules, actin filaments, and intermediate filaments
  • Mutations in the gene encoding the fibroblast growth factor receptor 3
    Achondroplasia
  • *Mutations in the gene encoding the LDL receptor
    Familial hypercholesterolemia
  • *Mutations in the gene encoding the CFTR protein, a Cl- transporter
    Cystic fibrosis
  • mutations in the genes encoding ion channels in the heart
    Congenital long QT syndrome
  • Mutations in the gene encoding a copper dependent ATPase
    Wilson disease
  • * mutations in the genes encoding spectrin or other structural proteins in the red cell membrane
    Hereditary spherocytosis