2023-03-11T22:25:04+03:00[Europe/Moscow] en true <p>form micelles that solubilize hydrophobic lipid materials </p>, <p>Polymyxin B, Colistin, Coly-mycin</p>, <p>Gm - </p>, <p>injectable salt, opthalmic ointment/ solution, and otic suspension?</p>, <p>polymyxin b; not excreted by kidneys</p>, <p>c</p>, <p>b</p>, <p>d</p>, <p>diaminobutryic; lysine </p>, <p>severe hospitalized/resistant pseudomonas; topical pseudomonas eye infection</p>, <p>selectively binds to negatively charged LPS of gm - bacteria ; causing disruption of membrane and allowing for molecules to flow inside</p>, <p>b,d </p>, <p>b</p>, <p>pseudomonas in CF patients</p>, <p>pseudomonas in ear infections </p>, <p>b</p>, <p>d</p>, <p>MDR KES, AR pseudomonas, pen/ceph resistant pseudomonas </p>, <p>b</p>, <p>increases toxicity</p>, <p>increases neuromuscluar blockade </p>, <p>Daptomycin</p>, <p>Gm +; MRSA &amp; VRMRSA</p>, <p>inserts into cytoplasmic membrane; mimics phospholipids, binds to chaperone proteins; forms pores that allow for passage of small ions &amp; molecules to depolarize membrane</p>, <p>staph endocarditis</p>, <p>a</p>, <p>statins</p>, <p>q48h</p>, <p>muscle damage/pain</p>, <p>iv methylprednisone or oral prednisone</p>, <p>contains a lipid tail</p>, <p>polymyxin b, daptomycin</p>, <p>iv</p>, <p>reduces number of chaperone proteins; decreased binding </p>, <p>depsi peptide ester bond shield it from proteasome</p>, <p>cidal</p>, <p>iv, im, inhalation, otic suspension </p> flashcards
Cationic & Anionic Detergents

Cationic & Anionic Detergents

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  • form micelles that solubilize hydrophobic lipid materials

    How do anionic detergents work?

  • Polymyxin B, Colistin, Coly-mycin

    What are our PolyPeptides (Cationic Detergents)?

  • Gm -

    What is the spectrum for Polypeptide detergents?

  • injectable salt, opthalmic ointment/ solution, and otic suspension?

    What are the dosage forms for Polymyxin b?

  • polymyxin b; not excreted by kidneys

    Which detergent is NOT used to treat UTI? Explain

  • c

    Which detergent is only available as an otic suspension (drops)?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • b

    Which detergent is a prodrug?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • d

    Which detergent produces produces a positive charge at physiological pH?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • diaminobutryic; lysine

    Polymyxin B produces _______ acid at physiological pH due to protonation; this acid behaves similarly to __________.

  • severe hospitalized/resistant pseudomonas; topical pseudomonas eye infection

    Polymyxin tx?

  • selectively binds to negatively charged LPS of gm - bacteria ; causing disruption of membrane and allowing for molecules to flow inside

    What is the MOA of polypeptides/ cationic detergents?

  • b,d

    Which detergent causes nephrotoxicity or neurotoxicity?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • b

    Which detergent CAN be used to treat UTI?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • pseudomonas in CF patients

    Coly-Mycin M inhalation form is used to treat ?

  • pseudomonas in ear infections

    Coly-Mycin M topical form is used to treat?

  • b

    Which detergent has dose-dependent nephrotoxicity?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • d

    Which detergent can be used to treat Pseudomonas eye infections?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • MDR KES, AR pseudomonas, pen/ceph resistant pseudomonas

    What is the spectrum of Coly-Mycin M?

  • b

    Which detergent has drug interactions with muscle relaxants & Amikacin?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • increases toxicity

    How does detergent/muscle relaxant drug interaction affect a patient?

  • increases neuromuscluar blockade

    How does detergent/amikacin drug interaction affect a patient?

  • Daptomycin

    What is our Cyclic LipoPeptide/ Anionic peptide?

  • Gm +; MRSA & VRMRSA

    What is the spectrum of Daptomycin?

  • inserts into cytoplasmic membrane; mimics phospholipids, binds to chaperone proteins; forms pores that allow for passage of small ions & molecules to depolarize membrane

    What is the MOA of Daptomycin?

  • staph endocarditis

    What condition does Daptomycin treat?

  • a

    Which detergent has an FDA warning for life threatening eosinophilic pneumonia caused by WBC's?

    a) Daptomycin

    b) Coly-Mycin

    c) Colistin

    d Polymyxin B

  • statins

    Which drugs cause drug interactions with Daptomycin?

  • q48h

    How do we dose a patient who needs Daptomycin, but has kidney failure?

  • muscle damage/pain

    What are side effects associated with Daptomycin?

  • iv methylprednisone or oral prednisone

    How do we treat life-threatening eosinophilic pneumonia?

  • contains a lipid tail

    What is unique about Polymyxin B's structure?

  • polymyxin b, daptomycin

    Which detergents are derived from natural products?

  • iv

    What is the dosage form of Daptomycin?

  • reduces number of chaperone proteins; decreased binding

    How does Daptomycin-resistant bacteria withstand the detergent?

  • depsi peptide ester bond shield it from proteasome

    What is unique about Daptomycin's structure?

  • cidal

    Daptomycin is a ________ detergent.

  • iv, im, inhalation, otic suspension

    What are the dosage forms for coly-mycin?