form micelles that solubilize hydrophobic lipid materials
How do anionic detergents work?
Polymyxin B, Colistin, Coly-mycin
What are our PolyPeptides (Cationic Detergents)?
Gm -
What is the spectrum for Polypeptide detergents?
injectable salt, opthalmic ointment/ solution, and otic suspension?
What are the dosage forms for Polymyxin b?
polymyxin b; not excreted by kidneys
Which detergent is NOT used to treat UTI? Explain
c
Which detergent is only available as an otic suspension (drops)?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
b
Which detergent is a prodrug?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
d
Which detergent produces produces a positive charge at physiological pH?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
diaminobutryic; lysine
Polymyxin B produces _______ acid at physiological pH due to protonation; this acid behaves similarly to __________.
severe hospitalized/resistant pseudomonas; topical pseudomonas eye infection
Polymyxin tx?
selectively binds to negatively charged LPS of gm - bacteria ; causing disruption of membrane and allowing for molecules to flow inside
What is the MOA of polypeptides/ cationic detergents?
b,d
Which detergent causes nephrotoxicity or neurotoxicity?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
b
Which detergent CAN be used to treat UTI?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
pseudomonas in CF patients
Coly-Mycin M inhalation form is used to treat ?
pseudomonas in ear infections
Coly-Mycin M topical form is used to treat?
b
Which detergent has dose-dependent nephrotoxicity?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
d
Which detergent can be used to treat Pseudomonas eye infections?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
MDR KES, AR pseudomonas, pen/ceph resistant pseudomonas
What is the spectrum of Coly-Mycin M?
b
Which detergent has drug interactions with muscle relaxants & Amikacin?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
increases toxicity
How does detergent/muscle relaxant drug interaction affect a patient?
increases neuromuscluar blockade
How does detergent/amikacin drug interaction affect a patient?
Daptomycin
What is our Cyclic LipoPeptide/ Anionic peptide?
Gm +; MRSA & VRMRSA
What is the spectrum of Daptomycin?
inserts into cytoplasmic membrane; mimics phospholipids, binds to chaperone proteins; forms pores that allow for passage of small ions & molecules to depolarize membrane
What is the MOA of Daptomycin?
staph endocarditis
What condition does Daptomycin treat?
a
Which detergent has an FDA warning for life threatening eosinophilic pneumonia caused by WBC's?
a) Daptomycin
b) Coly-Mycin
c) Colistin
d Polymyxin B
statins
Which drugs cause drug interactions with Daptomycin?
q48h
How do we dose a patient who needs Daptomycin, but has kidney failure?
muscle damage/pain
What are side effects associated with Daptomycin?
iv methylprednisone or oral prednisone
How do we treat life-threatening eosinophilic pneumonia?
contains a lipid tail
What is unique about Polymyxin B's structure?
polymyxin b, daptomycin
Which detergents are derived from natural products?
iv
What is the dosage form of Daptomycin?
reduces number of chaperone proteins; decreased binding
How does Daptomycin-resistant bacteria withstand the detergent?
depsi peptide ester bond shield it from proteasome
What is unique about Daptomycin's structure?
cidal
Daptomycin is a ________ detergent.
iv, im, inhalation, otic suspension
What are the dosage forms for coly-mycin?