Antineoplastic drugs

2017-07-29T07:43:15+03:00[Europe/Moscow] en true Temsirolimus, Vorinostat, Fosfestrol, Azathioprine, Aminolevulinic acid, Mitomycin C, Anagrelide, Celecoxib, Miltefosine, Regorafenib, Everolimus, Asparaginase, Lenalidomide, HN3 (nitrogen mustard), Idelalisib, Resimmune, Tamibarotene, Alitretinoin, Lonidamine, 3,3'-Diindolylmethane, Aceglatone, Acutissimin A, Azaserine, Pegaspargase, Pegdinetanib, Trifluridine, Biricodar, Elsamitrucin, Enocitabine, Epitiostanol, Exisulind, O6-Benzylguanine, Selumetinib, Pembrolizumab, Neocarzinostatin, Avelumab, Losoxantrone, Trabectedin, Amsacrine, 2-Methoxyestradiol, Denileukin diftitox, Eribulin, Mitotane, Bexarotene, Anthramycin, Etoglucid, Quisinostat, OSU-03012, Kedarcidin, Steganacin, Trifluridine/tipiracil, Vapreotide, Masoprocol, Megestrol acetate, Melengestrol, Melengestrol acetate, Mepitiostane, Mitoguazone, Nivolumab, Romidepsin, Tretinoin, Imiquimod, Resiquimod, Ingenol mebutate, Lucanthone, Lurtotecan, Abexinostat, Apaziquone, Buthionine sulfoximine, Efaproxiral, Methyl aminolevulinate flashcards Antineoplastic drugs
Click to flip
  • Temsirolimus
    Temsirolimus (CCI-779) is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the U.
  • Vorinostat
    Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC).
  • Fosfestrol
    Fosfestrol (INN, BAN, JAN) (brand names Honvan, Difostilben, Fosfostilben, Fostrolin, Stilbol, Stilphostrol, Vagestrol, among others), also known as diethylstilbestrol diphosphate (USAN), abbreviated as DESDP or DESP, is a synthetic, non-steroidal estrogen of the stilbestrol group that is or has been used in the treatment of prostate cancer.
  • Azathioprine
    Azathioprine (AZA), also known by its brand name Imuran, is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues.
  • Aminolevulinic acid
    δ-Aminolevulinic acid (dALA or δ-ALA or 5ala or 5-aminolevulinic acid ) is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants.
  • Mitomycin C
    Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity.
  • Anagrelide
    Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets.
  • Celecoxib
    Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID).
  • Miltefosine
    Miltefosine (trade names Impavido and Miltex) is a broad-spectrum phospholipid antimicrobial drug.
  • Regorafenib
    Regorafenib (BAY 73-4506, commercial name Stivarga) is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK).
  • Everolimus
    Everolimus (INN) (/ˌɛvəˈroʊləməs/) (earlier code name RAD001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR).
  • Asparaginase
    Asparaginase (EC 3.5.1.1, USAN) or Colaspase (BAN) is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid.
  • Lenalidomide
    Lenalidomide (trade name Revlimid) is a derivative of thalidomide introduced in 2004.
  • HN3 (nitrogen mustard)
    Tris(2-chloroethyl)amine is the organic compound with the formula N(CH2CH2Cl)3.
  • Idelalisib
    Idelalisib (trade name Zydelig zye-DEL-ig, codenamed GS-1101 or CAL-101) is a drug used for the treatment of certain hematological malignancies.
  • Resimmune
    Resimmune or A-dmDT390-bisFv(UCHT1) is an experimental drug — an anti-T cell immunotoxin — that is being investigated for treatment of T cell blood cancers such as cutaneous T cell lymphoma (CTCL).
  • Tamibarotene
    Tamibarotene (brand name: Amnolake), also called retinobenzoic acid, is orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity against acute promyelocytic leukaemia (APL) .
  • Alitretinoin
    Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A.
  • Lonidamine
    Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells.
  • 3,3'-Diindolylmethane
    3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and kale.
  • Aceglatone
    Aceglatone (Glucaron) is an antineoplastic drug available in Japan.
  • Acutissimin A
    Acutissimin A is a flavono-ellagitannin, a type of tannin formed from the linking of a flavonoid with an ellagitannin.
  • Azaserine
    Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine.
  • Pegaspargase
    Pegaspargase /pəˈɡæspərɡeɪz/, trade name Oncaspar, is a modified enzyme used as an antineoplastic agent.
  • Pegdinetanib
    Pegdinetanib (USAN; planned trade name Angiocept) is an investigational anti-cancer drug that acts as a selective antagonist of vascular endothelial growth factor receptor 2 (VEGFR-2), hindering vascularization of tumors.
  • Trifluridine
    Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye.
  • Biricodar
    Biricodar (INN, codename VX-710, marketed as the dicitrate salt under the trade name Incel) is a pharmaceutical drug released by Vertex Pharmaceuticals in 1999 to help treat ovarian cancer patients.
  • Elsamitrucin
    Elsamitrucin (elsamicin A) is a drug used in chemotherapy.
  • Enocitabine
    Enocitabine (INN, marketed under the brand name Sunrabin) is a nucleoside analog used as chemotherapy.
  • Epitiostanol
    Epitiostanol (INN, JAN) (brand name Thiodrol; developmental code name 10275 S), also known as epithioandrostanol or 2α,3α-epithio-5α-androstan-17β-ol, is a sulfur-containing, steroidal, potent antiestrogen as well as androgen and anabolic steroid derived from androstanol (5α-androstan-17β-ol) that was described in the literature in 1965 and has been marketed in Japan as an antineoplastic agent for the treatment of breast cancer since 1977.
  • Exisulind
    Exisulind (tentative trade name Aptosyn) is an antineoplastic agent.
  • O6-Benzylguanine
    O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine.
  • Selumetinib
    Selumetinib (AZD6244) is a drug that was discovered by Array BioPharma and was licensed to AstraZeneca.
  • Pembrolizumab
    Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized antibody used in cancer immunotherapy.
  • Neocarzinostatin
    Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus.
  • Avelumab
    Avelumab (MSB0010718C) is a fully human monoclonal PD-L1 antibody of isotype IgG1, currently in development by Merck KGaA, Darmstadt, Germany & Pfizer for use in immunotherapy, especially for treatment of NSCLC .
  • Losoxantrone
    Losoxantrone (biantrazole) is a anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone.
  • Trabectedin
    Trabectedin (also known as ecteinascidin 743 or ET-743) is an anti-tumor drug.
  • Amsacrine
    Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent.
  • 2-Methoxyestradiol
    2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol.
  • Denileukin diftitox
    Denileukin diftitox (trade name Ontak) is an antineoplastic agent, an engineered protein combining Interleukin-2 and Diphtheria toxin.
  • Eribulin
    Eribulin is an anticancer drug marketed by Eisai Co.
  • Mitotane
    Mitotane, also known as o,p'-DDD (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
  • Bexarotene
    Bexarotene (brand name: Targretin) is an antineoplastic (anti-cancer) agent approved by the U.
  • Anthramycin
    Anthramycin is a pyrrolobenzodiazepine antibiotic with antitumor activity.
  • Etoglucid
    Etoglucid is a drug used in chemotherapy.
  • Quisinostat
    Quisinostat (USAN; development code JNJ-26481585) is an experimental drug candidate for the treatment of cancer.
  • OSU-03012
    OSU-03012 (AR-12) is a celecoxib derivative with anticancer and anti-microbial activity.
  • Kedarcidin
    Kedarcidin is a chromoprotein antitumor antibiotic first isolated from an Actinomycete in 1992, comprising an ansa-bridged enediyne chromophore (shown) as well as an apoprotein that serves to stabilize the toxin in the Actinomycete.
  • Steganacin
    Steganacin is an antileukemic lignan isolated from Steganotaenia araliacea.
  • Trifluridine/tipiracil
    Trifluridine/tipiracil (trade name Lonsurf) is a combination drug for the treatment of metastatic colorectal cancer.
  • Vapreotide
    Vapreotide (Sanvar) is a synthetic somatostatin analog.
  • Masoprocol
    Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure.
  • Megestrol acetate
    Megestrol acetate (MGA) (INN, USAN, BAN, JAN) (brand names Megace, Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin of the 17α-hydroxyprogesterone group that is used in the treatment of breast and endometrial cancer and as an appetite stimulant.
  • Melengestrol
    Melengestrol (INN, BAN) is a steroidal progestin and antineoplastic agent which was never marketed.
  • Melengestrol acetate
    Melengestrol acetate (INN, USAN), also known as 17α-acetoxy-16-methylene-6-methyl-6-dehydroprogesterone, is a steroidal progestin that is used in veterinary medicine.
  • Mepitiostane
    Mepitiostane (INN, JAN) (brand name Thioderon), also known as epitiostanol 17-methyloxycyclopentyl ether, is a steroidal antiestrogen, androgen, and anabolic steroid that is used in Japan as an antineoplastic agent in the treatment of breast cancer and is also used in the treatment of anemia of renal failure.
  • Mitoguazone
    Mitoguazone (also known as methylglyoxal bis(guanylhydrazone) or MGBG) is a drug used in chemotherapy.
  • Nivolumab
    Nivolumab (nye vol' ue mab), marketed as Opdivo, is a human IgG4 anti-PD-1 monoclonal antibody used to treat cancer.
  • Romidepsin
    Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs).
  • Tretinoin
    Tretinoin is the pharmaceutical form of retinoic acid.
  • Imiquimod
    Imiquimod (INN) is a prescription medication that acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
  • Resiquimod
    Resiquimod (R-848) is a drug that acts as an immune response modifier, and has antiviral and antitumour activity.
  • Ingenol mebutate
    Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
  • Lucanthone
    Lucanthone is a drug used in chemotherapy.
  • Lurtotecan
    Lurtotecan is a semi-synthetic analog of camptothecin with antineoplastic activity.
  • Abexinostat
    Abexinostat (INN, formerly PCI-24781) is an experimental drug candidate for cancer treatment.
  • Apaziquone
    Apaziquone (tentative trade name EOquin) is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C.
  • Buthionine sulfoximine
    Buthionine sulfoximine (BSO) is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer.
  • Efaproxiral
    Efaproxiral (INN) is an analogue of the cholesterol drug bezafibrate developed for the treatment of depression, traumatic brain injury, ischemia, stroke, myocardial infarction, diabetes, hypoxia, sickle cell disease, hypercholesterolemia and as a radio sensitiser.
  • Methyl aminolevulinate
    Methyl aminolevulinate (MAL) is a drug used as a sensitizer in photodynamic therapy.