Hosam Mohamed-
a
Which do we use after surgery or severe life-threatening situations?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
-
b
Which do we use to replace coagulation factors ?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
-
c
Which is used to treat/prevent bleeding due to low platelets?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
-
d
Which is used to treat fibrinogen deficiencies?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
-
1 year
How long does Fresh Frozen plasma last?
-
binds ionically w heparin & LMWHs forming a stable complex; neutralizes anticoag effects
Protamine Sulfate MOA?
-
given by slow IV injection; avoid AE's of hypotension & CV collapse
How are Protamine Sulfate & KCentra administered?
Why?
-
phytonadione
-Vitamin K
-
f; slow reversal, may take 24 hours to see
Vitamin K reversal is rapid. T/F?
-
c
What is the preferred dose route for Phytonadione?
a) SQ
b) IM
c) PO
d) IV
-
resistance; fat soluble
Warfarin __________ can occur after use due to vitamin K being ________.
-
II, VII, IX, and X
Kcentra contains which clotting factors? (4)
-
a,c
Which reversal agent is given slowly?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
-
c
Which reversal agent has a BBW for thromboembolic disorders?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
c
Which is dosed based off of INR?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
d
Which is used specifically to reverse dabigatran?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
d
Which has to be protected from light?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
d
Which has to be refrigerated, but not frozen?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
rivaroxaban; apixaban
Andexxa is FDA approved to reverse ______ & ________. But can treat all factor Xa inhibitors.
-
e
Which can cause UTI & Pneumonia?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
e
Which uses a 20-gauge needle?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
low dose DOAC or last dose known > 8 hours ago
When do we use low dose Andexxa?
-
high dose DOAC or unknown dose; last dose < 8 hrs ago/unknown
When do we use high dose Andexxa?
-
NovoSeven
-recombinant human factor VIIa
-
f; used off label; only approved for hemophilia conditions
NovoSeven is FDA approved for reversal of VKA. T/F?
-
a
Which prosthetic valves require patients to be on anticoagulation therapy indefinitely?
a) mechanical
b) bioprosthetic
-
2.5-3.5
Any mitral valve INR =
-
2-3
Aortic valves INR=
-
b
Which prosthetic valves require patients to be on ASA 81 mg daily?
a) mechanical
b) bioprosthetic
-
recombinant analog that sequester circulating factor Xa inhibitors; reversing anti-factor xa activity
Andexxa MOA?
-
binds dabigatran with an affinity 350x higher than thrombin-dabigatran; irreversible complex formed
Idarucizumab MOA?
-
platelets
FFP has all of the inactive coagulating components EXCEPT _______.
-
UFH/LMWH dose
What is the Protamine Sulfate dose dependent on?
-
d
Which is used to reverse Dabigatran?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
-
rivaroxaban, apixaban
What is Andexxa used to reverse?
-
vitamin K, kcentra, novo7, FFP
What is used to reverse Warfarin? (4)
-
c
Which can only last 5 days + kept at room temperature?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
-
warfarin; DOACS
Fresh frozen Plasma is better at reversing ________ than it is at reversing _______.
-
Kcentra; vitamin k
_________ must be co-administered with ______ to maintain K-dependent
clotting factors.
-
c
Which has the fastest reversal of Vitamin K- Antagonists?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
