a
Which do we use after surgery or severe life-threatening situations?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
b
Which do we use to replace coagulation factors ?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
c
Which is used to treat/prevent bleeding due to low platelets?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
d
Which is used to treat fibrinogen deficiencies?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
1 year
How long does Fresh Frozen plasma last?
binds ionically w heparin & LMWHs forming a stable complex; neutralizes anticoag effects
Protamine Sulfate MOA?
given by slow IV injection; avoid AE's of hypotension & CV collapse
How are Protamine Sulfate & KCentra administered?
Why?
phytonadione
-Vitamin K
f; slow reversal, may take 24 hours to see
Vitamin K reversal is rapid. T/F?
c
What is the preferred dose route for Phytonadione?
a) SQ
b) IM
c) PO
d) IV
resistance; fat soluble
Warfarin __________ can occur after use due to vitamin K being ________.
II, VII, IX, and X
Kcentra contains which clotting factors? (4)
a,c
Which reversal agent is given slowly?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
c
Which reversal agent has a BBW for thromboembolic disorders?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
c
Which is dosed based off of INR?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
d
Which is used specifically to reverse dabigatran?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
d
Which has to be protected from light?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
d
Which has to be refrigerated, but not frozen?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
rivaroxaban; apixaban
Andexxa is FDA approved to reverse ______ & ________. But can treat all factor Xa inhibitors.
e
Which can cause UTI & Pneumonia?
a) protamine sulfate
b) vitamin k/ phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
e
Which uses a 20-gauge needle?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
low dose DOAC or last dose known > 8 hours ago
When do we use low dose Andexxa?
high dose DOAC or unknown dose; last dose < 8 hrs ago/unknown
When do we use high dose Andexxa?
NovoSeven
-recombinant human factor VIIa
f; used off label; only approved for hemophilia conditions
NovoSeven is FDA approved for reversal of VKA. T/F?
a
Which prosthetic valves require patients to be on anticoagulation therapy indefinitely?
a) mechanical
b) bioprosthetic
2.5-3.5
Any mitral valve INR =
2-3
Aortic valves INR=
b
Which prosthetic valves require patients to be on ASA 81 mg daily?
a) mechanical
b) bioprosthetic
recombinant analog that sequester circulating factor Xa inhibitors; reversing anti-factor xa activity
Andexxa MOA?
binds dabigatran with an affinity 350x higher than thrombin-dabigatran; irreversible complex formed
Idarucizumab MOA?
platelets
FFP has all of the inactive coagulating components EXCEPT _______.
UFH/LMWH dose
What is the Protamine Sulfate dose dependent on?
d
Which is used to reverse Dabigatran?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa
rivaroxaban, apixaban
What is Andexxa used to reverse?
vitamin K, kcentra, novo7, FFP
What is used to reverse Warfarin? (4)
c
Which can only last 5 days + kept at room temperature?
a) RBCs
b) Fresh Frozen Plasma
c) Platelet Concentrate
d) Cryoprecipitate
warfarin; DOACS
Fresh frozen Plasma is better at reversing ________ than it is at reversing _______.
Kcentra; vitamin k
_________ must be co-administered with ______ to maintain K-dependent
clotting factors.
c
Which has the fastest reversal of Vitamin K- Antagonists?
a) protamine sulfate
b) phytonadione
c) Kcentra
d) Idaruciziumab
e) Andexxa