2023-04-16T21:14:20+03:00[Europe/Moscow] en true <p>inhibits RNA transcription by inhibiting bacterial DNA-dependent RNA-polymerase </p>, <p>hepatic injury </p>, <p>induces P450s--decreases drug concentrations </p>, <p>mutation in RNA polymerase if used as long-term monotherapy</p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>d</p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>b</p> flashcards
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  • inhibits RNA transcription by inhibiting bacterial DNA-dependent RNA-polymerase

    MOA?

  • hepatic injury

    Adverse effects ?

  • induces P450s--decreases drug concentrations

    Drug interactions?

  • mutation in RNA polymerase if used as long-term monotherapy

    Resistance?

  • a

    Which drug can cause hyperuricemia?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • c

    Which drug can cause flu-like symptoms if a dose is missed?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • d

    Which drug is 1st line for MAC(Mycobacterium avium complex) ?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • d

    Which drug is the preferred agent in AIDS patients?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • a

    Which drug may have the best efficacy against TB?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • c

    Which drug has the worst P450 interactions?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • d

    Which drug can cause polymyalgia, polyarthralgia, decreased granulocytes, uveitis?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin

  • b

    Which drug is used to treat e.coli, IBS, hepatic encephalopathy, PMC?

    a) rifapentine

    b) rifaximin

    c) rifampin

    d) rifabutin