inhibits RNA transcription by inhibiting bacterial DNA-dependent RNA-polymerase
MOA?
hepatic injury
Adverse effects ?
induces P450s--decreases drug concentrations
Drug interactions?
mutation in RNA polymerase if used as long-term monotherapy
Resistance?
a
Which drug can cause hyperuricemia?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
c
Which drug can cause flu-like symptoms if a dose is missed?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
d
Which drug is 1st line for MAC(Mycobacterium avium complex) ?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
d
Which drug is the preferred agent in AIDS patients?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
a
Which drug may have the best efficacy against TB?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
c
Which drug has the worst P450 interactions?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
d
Which drug can cause polymyalgia, polyarthralgia, decreased granulocytes, uveitis?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin
b
Which drug is used to treat e.coli, IBS, hepatic encephalopathy, PMC?
a) rifapentine
b) rifaximin
c) rifampin
d) rifabutin