2023-03-14T18:06:23+03:00[Europe/Moscow] en true <p>broad; gm (+) &amp; gm(-); not active against anaerobes </p>, <p>they possess inherent resistance due to their lack of oxygen need for EDP1</p>, <p>KES, Pseudomonas, TB</p>, <p>inherent, chromosomal alteration of 30s ribosome, porin deletion, methylation of 16s ribosome, r-factors</p>, <p>ribosomal protection</p>, <p>rapid, horizontal</p>, <p>decreased ab binding, altered tRNA structure that allows for ab bound ribosome to maintain function, can bind to ribosome and remove ab</p>, <p>plasmid transfer of extrachromosomal R-factors</p>, <p>acetylation of amino groups; phosphorylation or adenylation of hydroxyl groups</p>, <p>nephrotoxicity, neuromuscular blockade, teratogenic </p>, <p>inhibits bacterial protein synthesis by binding to 30s ribosomal subunit; causing codon misreading and breaks polysomes</p> flashcards
Aminoglycosides: MOA, Spectrum, SE's

Aminoglycosides: MOA, Spectrum, SE's

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  • broad; gm (+) & gm(-); not active against anaerobes

    What is the spectrum for Aminoglycosides?

  • they possess inherent resistance due to their lack of oxygen need for EDP1

    Why are Anaerobes resistant to Aminoglycosides?

  • KES, Pseudomonas, TB

    What are some bacteria this drug is active against?

  • inherent, chromosomal alteration of 30s ribosome, porin deletion, methylation of 16s ribosome, r-factors

    What are specific methods of Amingoglycoside resistance (5)?

  • ribosomal protection

    -methylation of 16s ribosomal RNA; this is how a specific strain of streptomyces protects itself from the antibiotics it produces.

    - this is now present in bacteria especially Pseudomonas

  • rapid, horizontal

    Ribosomal protection transfers from Actinometes to bacteria through _________ transfer.

  • decreased ab binding, altered tRNA structure that allows for ab bound ribosome to maintain function, can bind to ribosome and remove ab

    What are the consequences of ribosomal protection? (3)

  • plasmid transfer of extrachromosomal R-factors

    What is considered the MOST important mechanism of Aminoglycoside resistance ?

  • acetylation of amino groups; phosphorylation or adenylation of hydroxyl groups

    How does R-factor work?

  • nephrotoxicity, neuromuscular blockade, teratogenic

    What are serious adverse effects associated with Aminoglycosides?

  • inhibits bacterial protein synthesis by binding to 30s ribosomal subunit; causing codon misreading and breaks polysomes

    Aminoglycoside MOA?