2023-05-07T02:22:03+03:00[Europe/Moscow] en true <p>nephrotoxicity (reversible); ototoxicity (irreversible) </p>, <p>passes through gm- porin channels; irreversibly binds to 30s ribosome &amp; blocks initiation complex at 50s; causes damage to membrane and proteins leak out; cidal</p>, <p>broad-spectrum</p>, <p>c</p>, <p>d</p>, <p>endocarditis, bacteremia, pyelonephritis </p>, <p>a</p>, <p>d</p>, <p>a</p>, <p>a</p>, <p>d</p>, <p>clarithromycin + azithromycin </p>, <p>qt elongation, P450 inhibition </p>, <p>b</p>, <p>legionella, chlamydia, mycoplasma </p>, <p>d</p>, <p>bind to 50s subunit; block translocation; block protein synthesis; static </p>, <p>c</p>, <p>b, e</p>, <p>d</p>, <p>f</p>, <p>UTIs </p>, <p>b</p>, <p>avoids efflux; increases ribosome binding </p>, <p>bronchitis, lyme disease, plague, ca-mrsa, syphilis, rti </p>, <p>a</p>, <p>a</p>, <p>b</p>, <p>b</p>, <p>a</p>, <p>d</p>, <p>VR-entero faecalis </p>, <p>false</p>, <p>Bind reversibly to the “A” site on the 30S ribosomal subunit; reversibly inhibits protein synthesis; static </p>, <p>Work synergistically together and with their own active metabolites; bind to 50s; cidal</p>, <p>Bind to 50S ribosomal subunit; prevent formation of 70S ribosomal initiation complex; inhibits translation; inhibits protein synthesis; both </p>, <p>epoxide group binds to isoleucine tRNA ligase; inhibits protein synthesis</p> flashcards
AGs, Tetracyclines, Macrolides

AGs, Tetracyclines, Macrolides

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  • nephrotoxicity (reversible); ototoxicity (irreversible)

    What are the side effects associated with Aminoglycosides?

  • passes through gm- porin channels; irreversibly binds to 30s ribosome & blocks initiation complex at 50s; causes damage to membrane and proteins leak out; cidal

    What is the MOA of Aminoglycosides? Static or Cidal?

  • broad-spectrum

    What is the spectrum for Aminoglycosides?

  • c

    Which Aminoglycoside is used in conjunction with isoniazid + ethambutol + rifampin to treat Tuberculosis?

    a) Plazomicin

    b) Tobramycin

    c) Streptomycin

    d) Neomycin

  • d

    Which Aminoglycoside is typically used for GI sterilization and wound washing?

    a) Plazomicin

    b) Tobramycin

    c) Streptomycin

    d) Neomycin

  • endocarditis, bacteremia, pyelonephritis

    What are general uses for AG's? (3)

  • a

    Which AG is used to treat UTI pyelonephritis?

    a) Plazomicin

    b) Tobramycin

    c) Streptomycin

    d) Neomycin

  • d

    Which AG can cause hepatic coma?

    a) Plazomicin

    b) Tobramycin

    c) Streptomycin

    d) Neomycin

  • a

    Which Macrolide has a BBW for liver toxicity & respiratory failure in patients with Myasthenia Gravis?

    a) telithromycin

    b) erythromycin

    c) azithromycin

    d) clindamycin

  • a

    Which Macrolide is the best for AB-resistant Strep. pneumoniae?

    a) telithromycin

    b) erythromycin

    c) azithromycin

    d) clindamycin

  • d

    Which Macrolide is used to treat Anaerobic infections?

    a) telithromycin

    b) erythromycin

    c) azithromycin

    d) clindamycin

  • clarithromycin + azithromycin

    Which Macrolides are used in conjunction to treat Mycoplasma RTI?

  • qt elongation, P450 inhibition

    What are general side effects with Macrolides?

  • b

    Which Macrolide stimulates Motilin, a GI stimulating hormone?

    a) telithromycin

    b) erythromycin

    c) azithromycin

    d) clindamycin

  • legionella, chlamydia, mycoplasma

    What bacteria are Macrolides active against? (3)

  • d

    Which Macrolide is used to treat CA-MRSA & acne?

    a) telithromycin

    b) erythromycin

    c) azithromycin

    d) clindamycin

  • bind to 50s subunit; block translocation; block protein synthesis; static

    Macrolide MOA? Static or Cidal?

  • c

    Which Tetracycline are used to treat Chlamydia eye infections?

    a) minocycline

    b) tigecycline

    c) doxycycline

    d) omadacycline

    e) eravacycline

    f) saracycline

  • b, e

    Which Tetracycline is used to treat complicated intra-abdominal infections?

    a) minocycline

    b) tigecycline

    c) doxycycline

    d) omadacycline

    e) eravacycline

    f) saracycline

  • d

    Which Tetracycline is used to treat community-acquired bacterial Pneumonia?

    a) minocycline

    b) tigecycline

    c) doxycycline

    d) omadacycline

    e) eravacycline

    f) saracycline

  • f

    Which Tetracycline has little effect on bacteria but is good for acne?

    a) minocycline

    b) tigecycline

    c) doxycycline

    d) omadacycline

    e) eravacycline

    f) saracycline

  • UTIs

    Eravacylcine is NOT used for ______.

  • b

    Which Tetracycline has a BBW for death?

    a) minocycline

    b) tigecycline

    c) doxycycline

    d) omadacycline

    e) eravacycline

    f) saracycline

  • avoids efflux; increases ribosome binding

    What special modifications were made to Tigecycline?

  • bronchitis, lyme disease, plague, ca-mrsa, syphilis, rti

    Doxycycline & Minocycline can treat what infections? (6)

  • a

    Which AB is used to treat Hospital-acquired VR- Entero faecium?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • a

    Which AB can cause injection site pain and is NOT to be used IM?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • b

    Which AB is used to treat CA-Pneumonia & nosocomial Pneumonia ?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • b

    Which AB can cause bone marrow suppression, anemia, and peripheral neuritis?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • a

    Which AB is used to treat bactermia, endocarditis, diverticulitis, and meningitis?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • d

    Which AB is used for MRSA-carriage in hospitals?

    a) synercid

    b) linezolid

    c) tedizolid

    d) mupirocin

  • VR-entero faecalis

    Synercid is not to be used on ________ it is 100% resistant.

  • false

    Synercid has been known to cause kidney toxicity & red-man syndrome. T/F?

  • Bind reversibly to the “A” site on the 30S ribosomal subunit; reversibly inhibits protein synthesis; static

    Tetracycline MOA? Static or cidal;

  • Work synergistically together and with their own active metabolites; bind to 50s; cidal

    Synercid MOA? Static or cidal?

  • Bind to 50S ribosomal subunit; prevent formation of 70S ribosomal initiation complex; inhibits translation; inhibits protein synthesis; both

    Linezolid/Tedizolid MOA? Static or Cidal?

  • epoxide group binds to isoleucine tRNA ligase; inhibits protein synthesis

    Mupirocin MOA?