nephrotoxicity (reversible); ototoxicity (irreversible)
What are the side effects associated with Aminoglycosides?
passes through gm- porin channels; irreversibly binds to 30s ribosome & blocks initiation complex at 50s; causes damage to membrane and proteins leak out; cidal
What is the MOA of Aminoglycosides? Static or Cidal?
broad-spectrum
What is the spectrum for Aminoglycosides?
c
Which Aminoglycoside is used in conjunction with isoniazid + ethambutol + rifampin to treat Tuberculosis?
a) Plazomicin
b) Tobramycin
c) Streptomycin
d) Neomycin
d
Which Aminoglycoside is typically used for GI sterilization and wound washing?
a) Plazomicin
b) Tobramycin
c) Streptomycin
d) Neomycin
endocarditis, bacteremia, pyelonephritis
What are general uses for AG's? (3)
a
Which AG is used to treat UTI pyelonephritis?
a) Plazomicin
b) Tobramycin
c) Streptomycin
d) Neomycin
d
Which AG can cause hepatic coma?
a) Plazomicin
b) Tobramycin
c) Streptomycin
d) Neomycin
a
Which Macrolide has a BBW for liver toxicity & respiratory failure in patients with Myasthenia Gravis?
a) telithromycin
b) erythromycin
c) azithromycin
d) clindamycin
a
Which Macrolide is the best for AB-resistant Strep. pneumoniae?
a) telithromycin
b) erythromycin
c) azithromycin
d) clindamycin
d
Which Macrolide is used to treat Anaerobic infections?
a) telithromycin
b) erythromycin
c) azithromycin
d) clindamycin
clarithromycin + azithromycin
Which Macrolides are used in conjunction to treat Mycoplasma RTI?
qt elongation, P450 inhibition
What are general side effects with Macrolides?
b
Which Macrolide stimulates Motilin, a GI stimulating hormone?
a) telithromycin
b) erythromycin
c) azithromycin
d) clindamycin
legionella, chlamydia, mycoplasma
What bacteria are Macrolides active against? (3)
d
Which Macrolide is used to treat CA-MRSA & acne?
a) telithromycin
b) erythromycin
c) azithromycin
d) clindamycin
bind to 50s subunit; block translocation; block protein synthesis; static
Macrolide MOA? Static or Cidal?
c
Which Tetracycline are used to treat Chlamydia eye infections?
a) minocycline
b) tigecycline
c) doxycycline
d) omadacycline
e) eravacycline
f) saracycline
b, e
Which Tetracycline is used to treat complicated intra-abdominal infections?
a) minocycline
b) tigecycline
c) doxycycline
d) omadacycline
e) eravacycline
f) saracycline
d
Which Tetracycline is used to treat community-acquired bacterial Pneumonia?
a) minocycline
b) tigecycline
c) doxycycline
d) omadacycline
e) eravacycline
f) saracycline
f
Which Tetracycline has little effect on bacteria but is good for acne?
a) minocycline
b) tigecycline
c) doxycycline
d) omadacycline
e) eravacycline
f) saracycline
UTIs
Eravacylcine is NOT used for ______.
b
Which Tetracycline has a BBW for death?
a) minocycline
b) tigecycline
c) doxycycline
d) omadacycline
e) eravacycline
f) saracycline
avoids efflux; increases ribosome binding
What special modifications were made to Tigecycline?
bronchitis, lyme disease, plague, ca-mrsa, syphilis, rti
Doxycycline & Minocycline can treat what infections? (6)
a
Which AB is used to treat Hospital-acquired VR- Entero faecium?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
a
Which AB can cause injection site pain and is NOT to be used IM?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
b
Which AB is used to treat CA-Pneumonia & nosocomial Pneumonia ?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
b
Which AB can cause bone marrow suppression, anemia, and peripheral neuritis?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
a
Which AB is used to treat bactermia, endocarditis, diverticulitis, and meningitis?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
d
Which AB is used for MRSA-carriage in hospitals?
a) synercid
b) linezolid
c) tedizolid
d) mupirocin
VR-entero faecalis
Synercid is not to be used on ________ it is 100% resistant.
false
Synercid has been known to cause kidney toxicity & red-man syndrome. T/F?
Bind reversibly to the “A” site on the 30S ribosomal subunit; reversibly inhibits protein synthesis; static
Tetracycline MOA? Static or cidal;
Work synergistically together and with their own active metabolites; bind to 50s; cidal
Synercid MOA? Static or cidal?
Bind to 50S ribosomal subunit; prevent formation of 70S ribosomal initiation complex; inhibits translation; inhibits protein synthesis; both
Linezolid/Tedizolid MOA? Static or Cidal?
epoxide group binds to isoleucine tRNA ligase; inhibits protein synthesis
Mupirocin MOA?