Hosam Mohamed-
Absorption
-movement of drug from site of application into bloodstream.
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gastric emptying, perfusion of GI tract, transit time
Oral absorption is affected by
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paracellular transport
Small molecule drugs move across the loosely knit (leaky) membranes via _______.
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distribution
-movement of drug from the bloodstream to a target or location in the body.
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glucuronidation
Most common Phase II biotransformation?
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oxidation
Most common Phase I biotransformation?
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active transport
Tubular secretion and biliary excretion always require __________.
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Weak base
____________ will be excreted if the pH is more acidic.
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Weak acid
___________ will be excreted faster if the pH is more basic.
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tissue perfusion
Distribution of small lipophilic drugs into various tissues is rate limited by ________.
