Absorption
-movement of drug from site of application into bloodstream.
gastric emptying, perfusion of GI tract, transit time
Oral absorption is affected by
paracellular transport
Small molecule drugs move across the loosely knit (leaky) membranes via _______.
distribution
-movement of drug from the bloodstream to a target or location in the body.
glucuronidation
Most common Phase II biotransformation?
oxidation
Most common Phase I biotransformation?
active transport
Tubular secretion and biliary excretion always require __________.
Weak base
____________ will be excreted if the pH is more acidic.
Weak acid
___________ will be excreted faster if the pH is more basic.
tissue perfusion
Distribution of small lipophilic drugs into various tissues is rate limited by ________.