• The function of the misfolded protein is almost always lost or reduced

• Misfolded proteins tend to self-associate and form aggregates

• Huntingtin Htt (Huntington’s)

• Amyloid-beta Ab (Alzheimer’s)

• prion protein (PrPSc) Creutzfeldt–Jakob disease and variant CJD

• alpha-synuclein (Parkinson’s disease)

• Serum amyloid A (AA amyloidosis)

• islet amyloid polypeptide IAPP (Type 2 Diabetes) and many more

• Other misfolded proteins result in cellular processing that lead to their degradation

• Cystic fibrosis

Review: Protein Structure and Function: The 3D Structure of Proteins (The Living Cell)