LOD scores can be calculated across the whole genome using genotype data for many genetic markers in multiple family members.

Parametric analysis specifies the pedigree structure and inheritance pattern (model).

Non-parametric analysis detects allele sharing between affected individuals.

LOD scores are additive: Different families linked to the same disease locus will increase the overall score.

A LOD score ≥ 3 is considered evidence for linkage.

A LOD score of 3 is equivalent to odds of 1000:1 that the observed linkage occurred by chance.

A LOD score ≤ -2 is considered evidence against linkage.

Review: Linkage Analysis (Genomics)