Immediate Reactions

•Vasoconstriction

•mast cell release Cytokines, chemokines(affect white blood cell

•C Reactive protein (CRP)- early indicator of inflammation, attaches to PAMP. released by liver

•Vascular reactions

•Blood vessels dilate

•Repair of damage and removal of damaged tissue

•Preventing further invasion

Late stages

•Swelling (edema) due to fluids and neutrophils (pus)

•Dilute toxins

•Deliver WBCs, oxygen, and fibrin to the site of the injury

•Resolution

•Wound is ‘cleared by macrophages

•Swelling gradually decreases as fluid is drained by lymphatic system

•if bad infection: B and T lymphocytes may be engaged

Review: lecture exam 3 you got this!