face; skin areas that rub against each other
Skin penetration of drug is greater on ______ & ________.
stratum corneum
________ is the major rate-limiting barrier to transdermal drug transport.
hydrophilic; transcellular/intracellular
______ drugs cross the cell barrier through the hydrated keratin in the cells through ______ route.
lipophilic; paracellular/intercellular
_______ drugs favor transport between cells in interstitial matrix through ______ route.
Paracellular pathway
______________ diffusion is the most common route for transdermal drug delivery.
zero
Percutaneous absorption utilizes __________ order of diffusion.
passive systems
-have been developed to improve bioavailability and increase the range of drugs for which transdermal delivery is a viable option
transdermal patches, nanoparticles, nanoemulsions
What are examples of Passive systems? (3)
active systems
-delivery system designed to deliver a wider variety of drug substances including biopharmaceuticals.
phoresis, microneedles
What are examples of active system? (2)
lipid; first step
The ________ component of the stratum corneum is considered an important determinant in the _______ of absorption.
initial
The _______ portion of the curve represents non-steady state diffusion.
linear
The ________ portion of the curve represents steady state diffusion.
<500 DA; <140 A
What is the MW & PSA?
sonophoresis
• is the application of low-frequency ultrasound acoustic waves to facilitate transdermal delivery
•is effective, because it facilitates drug movement by creating an aqueous path in the perturbed skin bilayer through cavitation
cavitation
-the formation, oscillation and, in some cases, collapse of bubbles in an ultrasonic pressure field
iontophoresis
-promotes the movement of ions or ionized compounds under the influence of a small externally applied potential difference which enhances skin penetration
photolithography
•the method of fabricating microneedles and has the advantage of being able to manufacture needles of various shapes using various materials.
microemulsion; nanoemulsion
_________ is thermodynamically stable while a ________ is not
200 NM
What is the optimal size for Nanoparticles?