wet granulation
-product is dampened and separated into particles prior to tablet compression.
hot melt extrusion
-homogenous and unstable.
damp or liquid material is inserted into a mold and allowed to dry
How are Molded tablets prepared?
high pressure applied directly to dry excipients to create tablet
How are Compressed tablets prepared?
Glidant
-pharmacologically inactive substance used to optimize the flow properties of tablet granulation or powder materials by decreasing inter-particle friction and cohesion
lubricant
-pharmacologically inactive substance added to the formulation to decrease friction between tablet’s surface and the die wall cavity in which the tablet was formed
lactose, mannitol, sorbitol
What are our diluents?
gelatin, tragacanth
What are our binders/ adhesives?
starch, cellulose
What are our disintegrants?
stearic acid, talc, waxes
What are our lubricants?
talc, silica
What are our glidants?
cornstarch, dyes/lakes
What are our colors?
does not move
In the Single Punch tablet press, lower punch ______ during compression.