The initial stimulus for the release of renin is a __________ in _________ ________ _________
decrease
systemic blood pressure
extrinsic control mechanisms
__________ ____ of the juxtaglomerular complex of the _________ release ______ through three different pathways
granular cells
kidneys
renin
extrinsic control mechanisms
Release of renin (1/3)
_______________ ______ in blood vessels of systemic circulation. renal __________ _____ activate receptors that signal _________ ____ to release ______
baroreceptor reflex
sympathetic nerves
granular cells
renin
extrinsic control mechanisms
Release of renin (2/3)
low __________ __________ of __________ __________ reduces glomerular __________ ____, the low __________ _______ in slower ______ ________ filtrate detected by ________ _________ signals _________ ____ to release ______
blood pressure
afferent arterioles
filtration rate
low sodium chloride
renal tubule
macula densa
granular cells
renin
extrinsic control mechanisms
Release of renin (3/3)
granular cells act as ________________, a decrease in _______ ________ _________ reduces ________ in granular cell __________ and stimulates them to release _______
mechanoreceptors
mean arterial blood
tension
membranes
renin
___________________ is produced in the liver
Angiotensinogen
_______ catalyzes the conversion which converts _____________ into _______________ __
renin
angiotensinogen
angiotensin I
______________________ is found in the lungs and converts Angiotensin I into Angiotensin II
angiotensin converting enzyme
extrinsic control mechanisms
Angiotensin II affects blood pressure in 3 ways
1. _____________ secretion by the __________ _________ causes sodium _____________ and potassium ___________ by _______ ________ _______, ________ follows the sodium which increases _______ volume resulting in increased ________ _________ _________
aldosterone
adrenal cortex
reabsorption
secretion
distal kidney tubules
water
systemic blood pressure
Angiotensin II affects blood pressure in 3 ways
2. the baroreceptor reflex also causes ______________ of _________ _________ increases _________ _________ resulting in increased _________ _____ _________
this is the only _______ _________ _________
vasoconstriction
systemic arterioles
peripheral resistance
systemic blood pressure
neural extrinsic control
extrinsic control mechanisms
Angiotensin II affects blood pressure in 3 ways
3. stimulation of the _________ _________ ________ releases __________ __________ affecting the _________ _________ of the kidneys to increase _____ _____________ and increases
posterior pituitary gland
antidiuretic hormone
collecting ducts
H2O reabsorption
systemic blood pressure
the _______ ____________ __________ mechanism is an example of ___________ _________ ________
renin angiotensin aldosterone
hormonal extrinsic control
GFR is controlled by changing the single variable of __________ ________ ___________
glomerular hydrostatic pressure
an increase in ____ increases ________ _______ which reduces ________ _________ and _________ _________
GFR
urine output
blood volume
blood pressure
intrinsic controls through ________ _______________ allow the kidneys to adjust its own __________ to _______ ______ despite ____________ in systemic arterial _______ _________, they occur when mean arterial pressure is between ___ and _____ mm
renal autoregulation
resistance
blood flow
fluctuations
blood pressure
80
180
Intrinsic controls/renal autoregulation
the stimulus for the _____________ _____________ ___ _________________ is a decrease in _________ _________ of _________ __________ which lowers the GFR, the decreased ________ of smooth muscle walls in afferent arterioles induces ___________ arteriole ____________ to raise the ____
myogenic mechanism of autoregulation
blood pressure
afferent arterioles
stretch
afferent
vasodilation
GFR
Intrinsic controls/renal autoregulation
the stimulus for the ____________________ ___________ ___ __________ is a decrease in _____ detected a decrease in ____ content of the ________ in the ascending nephron loop which triggers _________ ________ cells to induce ________ arteriole _____________
tubuloglomerular mechanism for autoregulation
GFR
salt
filtrate
macula densa
afferent
vasodilation
extrinsic controls occur when mean arterial pressure falls far outside the normal range either _____ or _______ mm hg
<80
>180