relievers/rescue drugs
-used for treating acute symptoms.
controllers/maintenance
-control the inflammatory/remodeling response
LT antagonists, theophylline, LAMA
What are our add-ons? (3)
histamine, leukotrienes, prostaglandins
IgE-induced mast cell degranulation results in the production of what
inflammatory mediators? (3)
SABA, ICS/formo, systemic steroids, SABA/SAMA
What are our relievers? (4)
ICS, ICS/LABA, mAB
What are our controllers?(3)
c
Which prevents the binding of IgE to mast cells?
a) Mepolizumab
b) Benralizumab
c) Omalizumab
d) Tezepelumab
e) Dupilumab
f) Reslizumab
e
Which is an IL-4Ra ab?
a) Mepolizumab
b) Benralizumab
c) Omalizumab
d) Tezepelumab
e) Dupilumab
f) Reslizumab
a,f
Which are IL-5 blockers?
a) Mepolizumab
b) Benralizumab
c) Omalizumab
d) Tezepelumab
e) Dupilumab
f) Reslizumab
b
Which is a IL-5 receptor blocker?
a) Mepolizumab
b) Benralizumab
c) Omalizumab
d) Tezepelumab
e) Dupilumab
f) Reslizumab
LOX
Inhibition of ______ enzyme decreases the synthesis of leukotrienes.
thymic stromal lymphopoietin
-activates the first steps of the inflammatory cascade in asthma.
ionotropic; chronotropic
Theophylline has a positive _____ & _____ effect.
levalbuterol
__________ is a single enantiomer SABA.
c
Which has a BBW for anaphylaxis?
a) Mepolizumab
b) Benralizumab
c) Omalizumab
d) Tezepelumab
e) Dupilumab
f) Reslizumab
mepolizumab, dupilumab, reslizumab
Which mABs are indicated for eosinophilic asthma? (3)
omalizumab
Which is indicated for allergic asthma?