sympathomimetics that stimulate a1 receptors in the nasal mucosa causing vasoconstriction
Decongestants MOA?
vasodilation; vasoconstriction
Increased __________ leads to congestion while increased __________ leads
to decongestion.
phenylephrine, oxymetazoline
What are the topical decongestants? (2)
Rhinitis medicamentosa
- a rebound vasodilation that can occur that results in more severe
congestion
b
Slower onset + longer DOA
a) topical decongestants
b) systemic decongestants
a
More prone to cause Rhinitis medicamentosa.
a) topical decongestants
b) systemic decongestants
b
Must avoid concomitant use of MAO inhibitors when taking.
a) topical decongestants
b) systemic decongestants
e
Which is a mast-cell stabilizer?
a) pseudoephedrine
b) Ipratropium Bromide
c) phenylephrine
d) montelukast
e) cromolyn sodium
b
Which is an anticholinergic nasal spray?
a) pseudoephedrine
b) Ipratropium Bromide
c) phenylephrine
d) montelukast
e) cromolyn sodium
d
Good in combination when a patient has asthma.
a) pseudoephedrine
b) Ipratropium Bromide
c) phenylephrine
d) montelukast
e) cromolyn sodium
defensive; underlying cause
Cough is a ________ reflex, therefore we should treat the ________.
c
Which is considered a local anesthetic?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
c
Which acts on respiratory stretch receptors?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
d
Which is a mu-opioid receptor agonist?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
b
Which increases the threshold for cough reflex?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
b
Which is to be avoided when a patient is taking MAO inhibitors?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
CYP2D6
Dextromethorphan is metabolized via _________.
a
Which is best for productive coughs?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine
increases the volume; reduces viscosity
Guaifenesin __________ & ___________ of mucus.
Benzonatate, codeine, dextromethorphan
What are the antitussives? (3)
guaifenesin
What are the expectorants?
pseudoephedrine, phenylephrine
What are the systemic decongestants? (2)
medullary cough center
Codeine is an opioid that acts on the ____________.
b
Which is an NMDA receptor antagonist?
a) Guaifenesin
b) Dextromethorphan
c) Benzonatate
d) Codeine