HLA-DRB1 isotype
Which genetic mutation can cause RA?
a
Which are auto-antibodies that precipitate when blood cools?
a) Rheumatoid Factor (RF0
b) Matrix Metalloprotease-1 (MMP-1)
c) Pannus
a
Which binds with IgG to form complexes that contribute to RA?
a) Rheumatoid Factor (RF0
b) Matrix Metalloprotease-1 (MMP-1)
c) Pannus
c
Which is a destructive vascular granulation tissue caused by
inflammation?
a) Rheumatoid Factor (RF0
b) Matrix Metalloprotease-1 (MMP-1)
c) Pannus
b
Which destroys Collagen I?
a) Rheumatoid Factor (RF0
b) Matrix Metalloprotease-1 (MMP-1)
c) Pannus
ESR, CRP
What are acute phase reactants involved in RA? (2)
HLA-B27 isotype
Which genetic mutation can cause Psoriatic Arthritis?
progressive joint destruction/deformities, dactylitis, enthesitis, progression to arthritis mutilans
What are the clinical manifestations of Psoriatic Arthritis? (4)
enthesitis
-inflammation of where a tendon or ligament attaches to a bone
physical exam, x-ray
How is Osteoarthritis diagnosed? (2)
<45 yo
When is OA more common in men?
> 45 yo
When is OA more common in women?
SLC family 2, ATP binding cassette subfamily G
Which genes are related to Gout? (2)
calcium pyrophosphate dihydrate
Which mineral is involved in Pseudogout?