heart block; bradycardia
BBs are CI in what conditions? (2)
reactive airway diseases, valvular heart disease, ED, Raynauds/ PAD
What conditions should we avoid BBs in? (4)
HFrEF/HFrpEF, stable ischemic heart disease, abdominal aortic aneurysm, arrhythmias
Compelling indications of BBs? (4)
vasodilators
Giving BBs with ______ can manage reflex tachycardia.
b
BBs & ________ can cause heart block.
a) ARBS
b) CCBs
c) ACEis
d) A2-agonists
d
BBs & ________ can cause bradycardia.
a) ARBS
b) CCBs
c) ACEis
d) A2-agonists
c
Useful in managing tremors and migraines.
a) mixed A & B- blockers
b) B1-selective
c) Nonselective B-Blockers
d) B1-selective + NO production
a
These possess the greatest risk of orthostasis.
a) mixed A & B- blockers
b) B1-selective
c) Nonselective B-Blockers
d) B1-selective + NO production
b
Mainly for reducing HR.
a) mixed A & B- blockers
b) B1-selective
c) Nonselective B-Blockers
d) B1-selective + NO production
b
Best for patients with reactive airway disease & diabetes
a) mixed A & B- blockers
b) B1-selective
c) Nonselective B-Blockers
d) B1-selective + NO production
f; lipophilic
Highly hydrophilic BBs tend to be the best for
tremors, thyroid, and migraines. T/f?
exhibit partial agonist activity at rest, no decrease in resting HR, good for sinus bradycardia; doesn't improve CV risk
What are the characteristics of drugs with Intrinsic Sympathomimetic Activity (ISA) *3
anti-arrhythmic properties, QTc prolongation/ seizures, no clinical advantage in HTN
What are the characteristics of drugs with Membrane Stabilizing Activity? (MSA) *3
mask; sweating
Beta-blockers can _____ the symptoms of hypoglycemia except ______.
clonidine, dilitazem, verapamil, amiodarone, NSAIDS
Which drugs should we avoid with BBs? (5)
increased rebound HTN w/ clonidine withdrawal
BBs + clonidine = (3)
heart block, AV block, bradycardia
BBs + CCB's = (3)
reduced efficacy
BBs + NSAIDS =
atenolol, nadolol
Which BBs are cleared renally? (2)
cocaine; stimulates a & b receptors; unopposed stimulation of a receptors increases PR, HR, BP
Which narcotic should especially be avoided when using BBs?
metoprolol, propranolol, carvedilol, labetalol
Which BBs are NOT once daily? (4)
upregulation & hypersensitivity of B-receptors
What is the mechanism behind BB withdrawal?
increased BP/HR, sweating, malaise
Symptoms of BB withdrawal? (3)
f; may have to restart BB
If symptoms present while tapering off, you should proceed with quitting. T/F?
propranolol, metoprolol, carvediolol
What are the Lipophilic Beta blockers? (3)
hydrophilic
__________ beta blockers are best for reducing sedation & dream SE's.
b
Which CR/XL/LA formulation can be split?
a) labetalol
b) metoprolol
c) carvedilol
d) propranolol
food; CR/XL/LA
________ helps smooth out the absorption of ________ products.