Components of the skin
Epidermis, Dermis, Hypodermis, Subcutaneous
Cells of the Epidermis
KeratinocytesMelanocytesMerkel cellsLangerhans cells
Stratum Basale
Stratum Spinosum
Defined by desmosomal presence
Stratum Granulosum
Stratum Lucidum
Stratum Corneum
Cornification = Keratinization
Keratinization
programmed cell death
Non-keratinocytes
Melanocytes: Dendritic cells, Clear cells on H & E
Langerhans cells
Special stains are required to visualize LC on histologically
Dermis
Functions of the Skin
BarrierPhysical and immuneCommunicationTemperature regulationSecretionStoragePigmentation