5'-3'
mRNA is translated in what direction?
methionine
what molecule does AUG represent?
tryptophan
what molecule does UGG represent?
1
For every codon, there is ___ amino acid (s)
initiation, elongation, termination,
What are 3 steps of translation?
by inhibiting protein synthesis
How do most antibiotics work?
-OH, -NH2, -SH
Nucleophiles contain which side chains?
primary protein structure
is the sequence of a chain of amino acids
secondary protein structure
occurs when the sequence of amino acids are linked by hydrogen bonds
tertiary protein structure
occurs when certain attractions are present between alpha helices and pleated sheets
quaternary protein structure
is a protein consisting of more than one amino acid chain
NME
-met is removed from newly synthesized protein
-occurs in 50% of all proteins
-occurs early in translation
-irreversible co-translational mechanism
alanine, cysteine, glycine, proline, serine, threonine, valine
NME occurs in what proteins that are located at the second position?
Molecular chaperones
proteins that assist in the folding of other proteins
Heat shock proteins (HSP)
a large class of chaperones that assist client proteins in folding
proteasomes
degrade proteins in highly regulated fashion and are responsible for the degradation of misfolded, damaged, or unneeded cellular proteins.
phosphorylation, acetylation, glycosylation, ubiquitination
What are some post-translational modifications?