_________ __________ and ___________ ___________ are the two forms of innate defenses
surface barriers
internal defenses
_________ ________ are the first line of defense comprised of _____ ______ and __________
Surface barriers
intact skin
mucosae
___________ __________ are the second line of defense and called into action whenever ___________ _________ have been penetrated, they utilize ___________, fever, antimicrobial proteins, ______________ and ________ _______ cells
internal defenses
surface barriers
inflammation
phagocytes
natural killer
___________________
3rd line of defense
Takes _________ to mount than the innate defense response
_________ and ________ immunity
Attacks identified foreign substances
____________ ___________ are the 3rd line of defense and takes longer to mount than the _______ defense response, it is comprised of ________ and __________ immunity that attack identified foreign substances
Adaptive Defenses
innate
humoral
cellular
Humoral immunity utilizes ___ _____
B cells
Cellular Immunity utilizes __ ______
T cells
_______________________________________
Occurs on the first exposure to a particular antigen
Primary immune response
________________________________________
Occurs on each subsequent exposure to a particular antigen
Secondary Immune Response
Primary Immune response 1/4
________ __________ where an ______ binds to a ____________ on a specific __ ___________, B cells without complementary receptors stay ___________
clonal selection
antigen
receptor
B lymphocyte
inactive
Primary Immune response 2/4
___________ to form a ______ of the activated __ _____
proliferation
clone
b cell
Primary Immune response 3/4
Cells of the _______ differentiate into ________ _______ which are
________-___________ effector cells
clone
plasma cells
antibody secreting
Primary Immune response 4/4
Clone cells that do not become plasma cells become long-lived __________ ____ which can mount an almost immediate _________ ___________ if the same ________ is encountered again in the future
Memory cells
humoral response
antigen
Secondary Immune Response (1/2)
1. Clones of __________ __ ______ from __________ __________ ___________ is primed to respond to ________ __________
memory B cell
primary immune response
same antigen
Secondary Immune Response (2/2)
2. Secondary response is larger and more rapid
more _______ _______
more ___________
more _________ __ ____
plasma cells
antibodies
memory b cells
____________ are immune system cells that ____________ foreign invaders in tissues
Macrophages
phagocytize
Immune system cells
________________
Kills parasitic worms
Complex role in allergies and asthma
eosinophils
Immune system cells
________________
phagocytize foreign invaders
neutrophils
Immune system cells
__________ _______ ______
Kills _________ cells
Kills virus-infected body cells _________ the immune system is activated
Not phagocytic
Kill with direct contact that induces programmed cell death ____________
Secretes chemicals that enhance the _____________ ___________
Natural Killer cells
cancer
before
apoptosis
inflammatory response
Phagocytosis 1/5
___________ ___________ bind with debris or _____________
phagocyte receptors
pathogens
Phagocytosis 2/5
2. _____________ form ________________ that eventually ________ the particles to form a _____________
phagocytes
pseudopods
engulf
phagosome
Phagocytosis 3/5
3. _____________ fuses with the _________ to form a ________________
Phagosome
lysosome
phagolysosome
Phagocytosis 4/5
4. Toxic compounds and ____________ _________ destroy ___________
lysosomal enzymes
pathogens
Phagocytosis 5/5
5. Sometimes ___________ of the ________ removes indigestible and residual materials
exocytosis
vesicle
Four Cardinal Signs of Inflammation
Signs to tell if acute inflammation is present
________
_____
________
_____
Redness
Heat
Swelling
Pain
Benefits of Inflammation 1/3
1. __________ the spread of damaging agents to nearby ______ by disposing of cell debris and _____________
prevents
tissues
pathogens
Benefits of Inflammation 2/3
2. Alerts the __________ ___________ ____________
adaptive immune system
Benefits of Inflammation 3/3
3. sets the stage for __________
repair
_________
Abnormally high body temperature, a systemic response to invading microorganisms
Fever
____________ and ____________ are exposed to ________ _____________ in the body
They release chemicals
_________ act on the __________________ to raise the body’s temperature above normal
leukocytes
macrophages
foreign substances
pyrogens
hypothalamus
Benefits of a fever 1/2
Causes _____ and ______ to hold on to ___ and ____
Makes them____ __________ to support ________ _______
liver
spleen
iron
zinc
less available
bacterial growth
Benefits of a fever 2/2
Speeds up the ________ _____ of _______ ____
Speeds up the _______ _________
metabolic rate
tissue cells
repair process
Harms of a fever
____ ________ can ________ protein structures
_________ and other body proteins
high fevers
destroy
enzymes
__________
Substance that provokes an immune response in the body
Antigen
Among the cell surface proteins that identify a cell as ___ is this group of glycoproteins called _____ __________
Millions of possible combinations make it unlikely for any two people other than identical twins to have the same proteins
self
MHC proteins
Each _______________ has a deep groove that holds 1 of 2 peptides
_____-______
_______-______
MHC protein
self-antigen
foreign-antigen
memory cells provide ________________ ___________
immunological memory
____________ __________ ______
Any several type of cell
macrophage, dendritic cell, B cell
antigen presenting cell
Antigen Presenting Cell
Engulfs _______
Presents fragments of them on its ________ __________ for recognition by __ _______ through the _________ ___________ ________
antigens
plasma membrane
T cells
adaptive immune system
_________ ___________
When B cells encounter antigens and produce antibodies against them
Active immunity
__________ ________ __________ _____________
Active Immunity is naturally acquired during _______ and ___ infections
During this we develop the signs and __________ of the ______
Naturally Active Acquired immunity
bacterial
viral
symptoms
disease
__________ ___________ _____________ ______________
mother’s ____________ cross the _________ and enter _____ __________ and during breastfeeding after birth
Baby is protected from antigens the mother has been exposed to for several months after birth
Naturally Passive Acquired Immunity
antibodies
placenta
fetal circulation
__________ _______ ___________ ___________
__ ______ are not challenged by the ______
______________ ____________ does not occur
Protection provided by the _________ ___________ ends when they naturally degrade in the body
Artificially Passive Acquired Immunity
B cells
antigen
immunological memory
donated antibodies
__________ _____________
Instead of being made by plasma cells, the antibodies are obtained from the serum of an immune human or animal donor
Passive Immunity
__________________________
__________ contain ___________ that are dead or ____________
Living but extremely weakened
Artificially Active Acquired Immunity
vaccines
pathogens
attenuated
benefits of artificially active acquired immunity
Primes the immune system for the stronger ________ _________
Spares the body from having to suffer to acquire __________ _______ _______ __________
Weakened _________ stimulate _______ production and promote __________ ___________
secondary response
natural active acquired immunity
antigens
antibody
immunological memory