True
Cephalosporin C (natural product) is not used clinically. T/F?
cepham has less ring strain
What is the difference between the penam nucleus & the cepham nucleus?
Ampicillin; Gm + & Gm -
Cephalosporin has a similar spectrum to what penicillin? What is the spectrum?
less
Cephalosporin is ___ potent to organisms that are susceptible in both classes.
allergic
Cephalosporin has far fewer ________ reactions.
Penicillin
What is more active on penicillinases? Cephalosporin or Penicillin?
Gm+
What kind of Pen'ase strains does cephalosporin act on?
moderate like ampicillin/amoxicillin
What is the spectrum for 1st gen Cephalosporins?
1st gen
Which generation has the best activity against Gm+?
a
Which generation is susceptible to cephalosporinases?
a) 1st gen
b) 2nd gen
c) 3rd gen
d) 4th gen
e) 5th gen
b
Which generation is stable/resistant to penicillinases and some cephalosporinases?
a) 1st gen
b) 2nd gen
c) 3rd gen
d) 4th gen
e) 5th gen
c,d,e
Which generation is stable/resistant to penicillinases and many cephalosporins?
a) 1st gen
b) 2nd gen
c) 3rd gen
d) 4th gen
e) 5th gen
a
Which generation has a short half-life and requires frequent dosing?
a) 1st gen
b) 2nd gen
c) 3rd gen
d) 4th gen
e) 5th gen
c,d,e
Which generations are active against Pseudomonas & Enterobacteriaceae?
a) 1st gen
b) 2nd gen
c) 3rd gen
d) 4th gen
e) 5th gen
c
What is an example of a narrow-spectrum antibiotic?
a) gm + and some gm-
b) gm + and many gm-
c) gm+ only
a
What is an example of an extended-spectrum antibiotic?
a) gm + and some gm-
b) gm + and many gm-
c) gm+ only
b
What is an example of a broad-spectrum antibiotic?
a) gm + and some gm-
b) gm + and many gm-
c) gm+ only
cephalexin, cefadroxil, cefazolin
What are our first generation cephalosporins?
cefazolin
Which first-gen cephalosporin is used parenterally or iv/im?
1st gen; cefaclor (2nd gen)
A cephalosporin with its first four letters "cefa" is what gen? Exception?
4th gen
A cephalosporin that ends in pime is what gen?
3rd gen; cefuroxime (2nd gen)
A cephalosporin that ends in one, me, or ten is what gen? Exception?