macrolides, tetracyclines, linezolid, tedizolid, clindamycin, lefamulin
What are our static agents? (6)
aminoglycosides, tetracyclines
Which agents act at the 30s subunit? (2)
Synercid, erythromycin/macrolides, lincosamides, linezolid, lefamulin, aminoglycosides
Which agents act at the 50s subunit? (6)
efflux pump, porin channel deletion, beta-lactamase, binding site mutation
What are the mechanisms of bacterial resistance (4)?
E. faecalis, anaerobes, MRSA, P. aeruginosa
Which bacteria are our Beta-Lactam AB active against? (4)
carbapenem, 1st & 2ng gen ceph, BLICs
Which beta-lactams cannot cross into the CNS? (3)
vancomycin
What is our Glycopeptide?
MRSA, E.faecalis, Anaerobes (+)
Which bacteria is Vancomycin active against? (3)
doxycycline, tigecycline, omadacycline, minocycline, tetracycline, eravacycline
What are our tetracyclines? (6)
MRSA, Enterococcus
Which bacteria are tetracyclines active against? (2)
clindamycin
What is our lincosamide?
polymyxin, aminoglycoside, aztreonam, fosfomycin, zosyn, ceftazidime, cefepime, ceftolozane, carbapenem, fq's, nitrofurantoin
What agents cover Pseudomonas? (11)
-floxacin suffix
What are the FQ's?
daptomycin
What is our lipopeptide?
-vancin suffix
What are our lipoglycopeptides?
bactrim; sulfamethoxazole + trimethoprim
What is our folate antagonist? What drugs make this up?
metrondiazole
What is our nitroimidazole?
aztreonam
What is our Monobactam?
lefamulin
What is our pleuromutilin?
ceftaroline, vancomycin, tetracyclines, daptomycin, lipoglycopeptides, delafloxacin, clindamycin, bactrim, linezolid, fosfomycin, lefamulin
Which drugs cover MRSA? (11)
GI, bones, skin, lungs
Where are Tetracyclines active in the body? (4)
MRSA, Enterococcus
Which bacteria are Tetracyclines active against? (2)
everywhere except CNS & lungs
Where is Daptomycin active in the body?
RT, eyes, ears, nose, GI
Where are macrolides active in the body? (5)
atypicals
Which bacteria are Macrolides active against?
MRSA, VR-Entero
Which bacteria are Lipoglycopeptides active against? (2)
everywhere except CNS
Where are Aminoglycosides active in the body?
bladder only
Where is nitrofurantoin active in the body?
bladder + prostate
Where is Fosfomycin active in the body? (2)
lungs + genitals
Where is Lefamulin active in the body? (2)
Moxifloxacin
Which Fluoroquinolones are active against anaerobes?
ciprofloxacin, delafloxacin, levofloxacin
Which Fluoroquinolones are active against Pseudomonas? (3)
delafloxacin
Which Fluoroquinolones are active against MRSA?
MRSA, VR-entero
Which bacteria are Oxazolidinones active against? (2)
MRSA, anaerobes (+)
Which bacteria are Lincosamides active against? (2)
GI, skin, bones, lungs
Where is Clindamycin active in the body? (4)
MRSA
What is Bactrim active against?
d
Polymyxin B does not make into what organ?
a) brain
b) GI
c) blood
d) kidneys
Pseudomonas
Polymyxin B is active against?
enterococcus, pseudomonas
Nitrofurantoin is active against what? (2)
MRSA, VR-entero, pseudomonas
Fosfomycin is active against what? (3)
MRSA, atypicals
Lefamulin is active against? (2)
Pseudomonas
What is Monobactam used for?
Lungs, GI, Urine (not moxi), CNS, blood
Where do FQ's act? (5)