inhibits neuraminidase from cleaving the receptor on host cell; preventing the budding of the virus, altering aggregation and release
What is the MOA of neuraminidase inhibitors?
5 days
How long does neuraminidase treatment last?
10 days
How long does neuraminidase prophylaxis last?
-amivir suffix
How can we tell our Neuraminidase inhibitors apart?
N&V, neuropsychiatric events, abdominal pain
What are the general AE's associated with Neuraminidase inhibitors? (3)
b,d
Which is predominately metabolized in the liver?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
a
Which is absorbed via inhalation?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
b
Which has dose adjustments for renal impairment?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
c
Which is excreted 90% unchanged in the urine?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
a
Which causes bronchospasms, throat pain, and cough?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
c
Which can cause increased serum glucose?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
c,d
Which can cause hypersensitivity and skin reactions?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
d
Which is only approved for a single dose?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
inhibits endonuclease of a selective polymerase acidic protein required for gene transcription inhibiting replication
What is the MOA of Baloxavir Marboxil (Xofluza)?
d
Which has activity against strains resistant to neuraminidase inhibitors?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
d
Which is ONLY indicated for treatment?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
d
Which is a prodrug?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)
UGT1A3, CYP3A4
What are the CYPs responsible for metabolizing Baloxavir?
d
Which can cause swollen tongue?
a) Zanamivir
b) Oseltamivir
c) Peramivir
d) Baloxavir Marboxil (Xofluza)