can donate H+
An acid is a substance that ______
accept H+
A base is a substance that ______
carbonic acid/bicarbonate, protein, phosphate
What are the major buffers within cells? (3)
hemoglobin
What is the buffer in erythrocytes?
proximal tubules; carbonic anhydrase
90% of reabsorption of bicarbonate occurs in the _______ of the nephron and is catalyzed by ________.
14-18
What is the normal RR?
7.35-7.45
What is the normal pH?
35-45 mmHg
What is the normal PCO2?
22-26 mEq/L
What is the normal HCO3?
drug overdose, head trauma, CVA (stroke), encephalitis
What can cause CNS-acute respiratory acidosis? (4)
Guillain-Barre syndrome, spinal cord injury, botulism, organophosphate poisoning
What can cause acute NM disease? (respiratory acidosis) *4
antidotes, bronchodilators, ventilator support
What are the treatment options for respiratory acidosis? (3)
alkali therapy
What treatment do we AVOID in respiratory acidosis?
supplemental oxygen, acetazolamide, stop offending drug
What treatments do we have for respiratory alkalosis? (3)
Na - (Cl + HCO3)
Anion Gap =
hypokalemia or hyperkalemia
A normal anion gap occurs because of what conditions? (2)
3-11 mEq/L
What is the range for the anion gap?
hyperchloremic
A normal anion gap is referred to as __________ acidosis.
diarrhea, fistulous disease, RTA type 1/2, CA inhibitors
What are the causes of Hypokalemic Anion gap? (4)
hypoaldosteronism, HCI, RTA type 4, K+ sparing diuretic
What are the causes of the Hyperkalemic Anion gap? (4)
>12
Which anion gap levels indicate elevated levels?
methanol, uremia, DKA, paraldehyde, isoniazid, lactic acidosis, ethylene glycol, salicylates
What are the causes of elevated anion gap? (9)
ureteral diversion, saline infusion, exogenous acid, diarrhea, CA inhibitors, adrenal insufficiency, RTA
What are the causes of the normal anion gap? (7)