Annual Meeting
November 6, 2015
Austin, TX
AGENDA
• Welcome
Dr. Steven Warach
• Summary of Accomplishments
Dr. Steven Warach
• NASCare
Dr. Mark Goldberg
• V-STOP II
Dr. Jane Anderson
• LESTER
Dr. Teddy Wu
•
• American Heart Go Red Women Network Grant (and other plans)
• Stroke Data Mapping Project
• Public comments
Christy Ankrom
Lone Star Stroke Consortium (LSS)
Primary Objectives
To improve the lives of Texans at risk for or suffering stroke.
To establish a state-wide clinical research network linking
academic health institutions with proven expertise in stroke
research to community stroke centers.
To conduct patient-centered research and therapeutic trials within
Texas aimed at the prevention and treatment of stroke.
Funding
LSS is funded from the Texas State Legislature through DSHS
Opportunities to leverage State funding for external grants in
support of specific projects are being pursued.
Lone Star Stroke Consortium
Operations and Structures
Member Organizations
Baylor College of Medicine
Seton Healthcare Family
Texas Tech Health Sciences Center
Texas Council on Cardiovascular Disease and Stroke
University of Texas Health Sciences Center Houston
University of Texas Health Sciences Center San Antonio
University of Texas Southwestern Medical Center
University of Texas System
Lone Star Stroke Consortium
Operations and Structures
Executive Committee (EC)
Baylor College of Medicine - Kent
Seton Healthcare Family - Warach
Texas Tech Health Sciences Center – Cruz-Flores
Texas Council on Cardiovascular Disease and Stroke - Rutledge
University of Texas Health Sciences Center Houston - Savitz
University of Texas Health Sciences Center San Antonio - Brey
UT Southwestern Medical Center - Goldberg
University of Texas System - Hurn
At Large - Grotta
Lone Star Stroke Consortium
Operations and Structures
Hub Coordinating Center – Principal Investigator
Baylor College of Medicine - Kent
Seton Healthcare Family - Warach
University of Texas Health Sciences Center Houston - Savitz
University of Texas Health Sciences Center San Antonio - Brey
University of Texas Southwestern Medical Center – Goldberg
• Five Hub Coordinating Centers
• Four Spoke Centers per Hub identified
• 25 Total enrolling research centers
Lone Star Stroke Hubs and Spokes
HUB: Baylor College of Medicine
CHRISTUS Hospital-St. Elizabeth
Valley Baptist Medical Center- Harlingen
St. Luke’s Woodlands
St. Luke’s Hospital at The Vintage
HUB:UT Southwestern Medical Center
Methodist Dallas Medical Center
Methodist Mansfield Medical Center
Good Shepherd Medical Center - Marshall
CHRISTUS St. Michael Hospital – Atlanta
Lone Star Stroke Hubs and Spokes
• HUB: Seton Healthcare Family - Austin
Seton Medical Center Williamson – Round Rock
Seton Medical Center Hays - Kyle
St. Joseph Regional Health Center – Bryan
Provident Hospital – Waco
• HUB: UT Health Science Center San Antonio
St. Luke’s Baptist Hospital
CHRISTUS Santa Rosa Hospital-Westover Hills
CHRISTUS Santa Rosa Hospital – New Braunfels
Texas Tech University Medical Center of El Paso
Lone Star Stroke Hubs and Spokes
HUB: The University Of Texas Health Science Center at
Houston
Citizens Medical Center- Victoria
Memorial Hermann – Southwest
Memorial Hermann Memorial City Hospital
Huntsville Memorial Hospital
Baptist Hospitals of Southeast Texas Beaumont Hospital
Lone Star Stroke Hubs and Spokes
HUB: Baylor College of Medicine
CHRISTUS Hospital-St. Elizabeth
Valley Baptist Medical Center- Harlingen
St. Luke’s Woodlands
St. Luke’s Hospital at The Vintage
HUB:UT Southwestern Medical Center
Methodist Dallas Medical Center
Methodist Mansfield Medical Center
Good Shepherd Medical Center - Marshall
CHRISTUS St. Michael Hospital – Atlanta
Lone Star Stroke Consortium
Operations and Structures
How New Projects Begin
Pilot studies – Proposed to and Approved by Executive Committee
Full studies Approved by Executive Committee and then External
Advisory Committee (EAC)
Dr. Karen Johnston – University of Virginia
Dr. Jeffrey Saver – UCLA
Dr. Maria Aguilar – Mayo Clinic
Dr. David Hess – Georgia Regents University
Lone Star Stroke Progress
• Lone Star Stroke has met its milestone driven deliverables as
specified in the DSHS contract
• Activity at five Hubs and 21 spoke partner sites has begun.
• The LSS research network serves annually more than seven
thousand Texans with stroke and cerebrovascular disease.
These patients comprise the population screened for inclusion
in LSS clinical studies.
• Four clinical research projects have been approved forward by
the External Advisory Committee and are in progress
Lone Star Stroke Progress
• The LSS was selected to make a presentation to the recent 2015
International Stroke Conference of the American Heart
Association, the world’s largest gathering of stroke researchers
• LSS Hub UTHSC Houston was named Regional Coordinating
Center for the NIH StrokeNet clinical trials network and LSS
centers are sites in StrokeNet, assuring a steady pipeline of
externally funded studies into Lone Star Stroke.
• LSS administrative coordinating core has been established at
the Austin Hub and the data management core at the UTHSC
Houston Hub.
www.lonestarstroke.org
• Website and newsletter to disseminate information
• Publications and Contributions of LSS investigators
Active Studies
CLOTBUST-ER. Status: completed.
Lone Star Stroke participated in this world-wide clinical trial that
evaluated a Texas technology to assess whether ultrasound
delivered into a clot improves the efficacy of tPA therapy for
stroke. Lone Star Stroke sites enrolled 26 patients, 9 by
telemedicine, about 5% of all patients. The study was halted and
analyses are on-going to determine whether any subgroups of
patients benefited.
• NASCare
• V-STOP II
• LESTER