Essential Biology Enzymes (Core 3.6 & AHL 7.6/ Op C2)
Student Name:
Due Date:
Candidate Number: 002171-
8.1 Metabolism
Specification UNDERSTANDING REQUIREMENTS
Specification guidance
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Metabolic pathways consist of chains and cycles of enzyme-catalysed reactions
Enzymes lower the activation energy of the chemical reactions that they catalyse
Enzyme inhibitors can be competitive or non-competitive
Metabolic pathways can be controlled by end-product inhibition
1. Define the term ‘metabolic pathway’
2. Explain the lowering of activation energy by enzymes.
3. A metabolic pathway is a chain or cycle of enzyme-controlled reactions.
a. List two examples of chain pathways.
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Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology Enzymes (Core 3.6 & AHL 7.6/ Op C2)
Student Name:
Due Date:
Candidate Number: 002171-
b. List two examples of cyclical pathways.
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4. In the space below, draw and annotate diagrams to explain the difference between
competitive and non-competitive inhibitors.
Competitive
Non-competitive
5. Distinguish between competitive and non-competitive inhibition.
Competitive
Non-competitive
Place of action
Active site
Allosteric site
Effect on enzyme
Conformational change of active site
Effect on activity
Fewer active sites available for reaction
Graph of effect of
inhibitor on activity
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology Enzymes (Core 3.6 & AHL 7.6/ Op C2)
Student Name:
Therapeutic example
Due Date:
Candidate Number: 002171-
Antabuse is a competitive inhibitor of
aldehyde oxidase, which breaks down the
toxic intermediate step of alcohol
metabolism. It is used in treating
alcoholism – if the patient drinks alcohol
he/she will feel very ill.
6. Explain how enzyme controlled pathways can be regulated by using end-product inhibition.
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Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology Enzymes (Core 3.6 & AHL 7.6/ Op C2)
Student Name:
Due Date:
Candidate Number: 002171-
Works Cited
1. Allott, Andrew. IB Study Guide: Biology for the IB Diploma. s.l. : Oxford University Press, 2007. 978-019-915143-1.
2. Mindorff, D and Allott, A. Biology Course Companion. Oxford : Oxford University Press, 2007. 978099151240.
3. Clegg, CJ. Biology for the IB Diploma. London : Hodder Murray, 2007. 978-0340926529.
4. Campbell N., Reece J., Taylor M., Simon. E. Biology Concepts and Connections. San Fransisco :
Pearson Benjamin Cummings, 2006. 0-8053-7160-5.
5. Taylor, Stephen. Science Video Resources. [Online] Wordpress, 2010.
http://sciencevideos.wordpress.com.
6. Burrell, John. Click4Biology. [Online] 2010. http://click4biology.info/.
7. IBO. Biology Subject Guide. [Online] 2007. http://xmltwo.ibo.org/publications/migrated/productionapp2.ibo.org/publication/7/part/2/chapter/1.html.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com