NAME _________________________________________________________ DATE ___________________
Mutation Worksheet
1. List the two types of mutations: ________________________ and __________________________.
2. A point mutation usually involves a __________________________, which can be a nonsense or
_______________________.
3. Frameshift mutations can either be an _______________________ or ________________________.
In the chart below, transcribe the DNA sequence into mRNA. Then use your codon chart to indicate
what amino acids are being coded for by the base sequences listed for the mRNA. Then, tell what type
of gene mutation is being illustrated. Choose from point mutation or frameshift mutation.
DNA sequence
mRNA sequence
Amino acid sequence
DNA sequence
mRNA sequence
Amino acid sequence
DNA sequence
mRNA sequence
Amino acid sequence
TACGCCAGTGGT
Original
TACCCCAGTGGT
TACCCAGTGGT
Complete the protein synthesis for the following DNA strands and show how mutations can cause
problems.
Original DNA sequence
Original mRNA sequence
Original Amino acid sequence
TACCCCGTCACCGCCTATATC
Mutated DNA #1
Mutated mRNA #1
Mutated AA #1
Type of Mutation (circle)
TACCCCGTCCACCGCCTATATC
Kind of Mutation (circle)
Mutated DNA #2
Mutated mRNA #2
Mutated AA #2
Type of Mutation (circle)
Kind of Mutation (circle)
Mutated DNA #3
Mutated mRNA #3
Mutated AA #3
Type of Mutation (circle)
Kind of Mutation (circle)
Point
Insertion
Frameshift
Deletion
Substitution
T A C C C C G T ___ A C C G C C T A T A T C
Point
Insertion
Frameshift
Deletion
Substitution
TACCACGTCACCGCCTATATC
Point
Insertion
Frameshift
Deletion
Substitution