Kathy Bailey Consultant Paediatric Rheumatologist Coventry and Warwickshire Common History and examination essential Missed diagnosis Simple problems require confident diagnosis Will become part of curriculum! permanent disability Limp stiffness swelling pain restriction of movement change in activities not using limb colour change in limb fever rash unwell HISTORY!!! ◦ Inflammatory ◦ mechanical ◦ non-organic/psychosomatic HISTORY!!! ◦ Inflammatory ◦ mechanical ◦ non-organic/psychosomatic ◦ Acute or chronic HISTORY!!! ◦ Inflammatory ◦ mechanical ◦ non-organic/psychosomatic ◦ Acute or chronic EXAMINATION ◦ objective signs HISTORY!!! ◦ Inflammatory ◦ mechanical ◦ non-organic/psychosomatic ◦ Acute or chronic EXAMINATION TESTS ◦ objective signs ◦ ??? Age of child Duration Symptoms Impact on activities Joints affected Family History Antecedents ◦ infection/trauma/ ◦ illness Age of child Duration Symptoms Impact on activities Joints affected Family History Antecedents ◦ infection/trauma/ ◦ illness Associated features: ◦ ◦ ◦ ◦ ◦ ◦ ◦ ◦ ◦ Constitutional Fever Rash Muscle weakness Eyes Weight loss GI bruising LN/mucusitis ....etc Height and weight Temp/pulse/BP General observations Rash Systems examination Urinalysis Paediatric Gait Arms Legs Spine www.arc.org.uk www.arc.org.uk/arthinfo/emedia.asp LOOK gait swelling deformity rash/colour changes FEEL heat swelling tenderness MOVE restriction +/- pain muscle strength Inflammatory Mechanical Psychosomatic Pain +/- + +++ Stiffness ++ +/- + Swelling +++ +/- +/- Sleep disturbance Instability +/- - ++ +/- ++ +/- Physical signs ++ + +/(or ++++) Inflammatory Infection Reactive Post Strep JIA Connective tissue diseases - SLE - JDMS - Scleroderma - Vasculitis Mechanical Idiopathic Hypermobility Pain Osteochondroses amplification syndromes - osgood-schlatter - Scheuermann’s - Perthes - Localised - Generalised Growing pains Chondromalacia patella Osteochondritis dissecans Slipped upper femoral epiphysis Acute Fever Localised tenderness hot Painful to move Raised inflammatory markers Fever Localised tenderness hot Painful to move Raised inflammatory markers JOINT ASPIRATION Site % Knee Hip 25 Ankle Elbow Organisms 39 14 12 Staph Aureus Tuberculosis Salmonella in sickle cell disease •May be history of recent infection •Single or multiple joints •No systemic features •Resolves by 6 weeks •Important to consider alternative diagnoses Reactive Vasculitis (small vessel) Palpable Purpura Arthralgia/Arthritis Abdominal pain Nephritis Headaches 1% of patients referred to paediatric rheumatology have underlying malignancy Acute Lymphoblastic Leukaemia ◦ Bone pain and arthralgia in 20-40% ◦ Suspect from history, exam, or blood count ◦ Bone Marrow aspirate Acute Lymphoblastic Leukaemia Neuroblastoma ◦ Commonest solid tumour under infants ◦ Bone pain from secondary spread ◦ Urinary excretion of catecholamine metabolites (VMA) Acute Lymphoblastic Leukaemia Neuroblastoma Primary Bone tumour ◦ Osteoid osteoma – benign ◦ osteosarcoma Features to raise concern: ◦ Bone pain (night time) ◦ Weight loss ◦ Night sweats or fevers ◦ Abnormal bloods ◦ Xray changes 5 of following 1. Fever >5 days; unresponsive to Abx 2. Non purulent conjunctivitis 3. lymphadenopathy >1.5cm 4. Rash - polymorphous 5. mucosal changes 6. extremities early - swelling/palmar erythema late – peeling OR 4 plus coronary artery aneurysms Prevent late sequel of coronary artery aneurysms ◦ Intravenous IVIG ◦ Aspirin – initially high, anti inflammatory then low dose, anti platelet Chronic JIA Juvenile Idiopathic Arthritis JRA Juvenile Rheumatoid Arthritis JCA Juvenile Chronic Arthritis JIA Juvenile Idiopathic Arthritis JRA Juvenile Rheumatoid Arthritis JCA Juvenile Chronic Arthritis JIA commonest rheumatic condition in childhood ◦ 30 – 150 per 100,000 10 years follow up ◦ 1/3 achieve remission ◦ 30% have severe functional limitations Fantini et al, ACR 1996 Disease of childhood onset ◦ under 16 years Persistence of arthritis ◦ 1 or more joints ◦ 6 or more weeks ◦ Exclusion of other diagnoses Defined by clinical features in first 6 months Defined by clinical features in first 6 months ◦ Oligoarthritis Persistent Extended 1-4 joints Girls >boys Younger age Best prognosis Girls >boys Younger age Best prognosis Associated with uveitis Defined by clinical features in first 6 months ◦ Oligoarthritis 1-4 joints ◦ Polyarthritis 5 or more joints RF positive RF negative Defined by clinical features in first 6 months ◦ Oligoarthritis ◦ Polyarthritis ◦ Psoriatic Arthritis 1-4 joints 5 or more joints Arthritis AND psoriasis OR Arthritis plus 2 of: Nail pitting Dactylitis First degree relative with confirmed psoriasis Defined by clinical features in first 6 months ◦ ◦ ◦ ◦ Oligoarthritis 1-4 joints Polyarthritis 5 or more joints Psoriatic Arthritis Enthesitis Related Arthritis Arthritis AND enthesitis OR Sacroiliac pain and HLA B27 Defined by clinical features in first 6 months ◦ Oligoarthritis 1-4 joints ◦ Polyarthritis 5 or more joints Persistent Extended RF positive RF negative ◦ Psoriatic Arthritis ◦ Enthesitis Related Arthritis ◦ Systemic Arthritis Daily fever for at least 2 weeks duration (quotidian for 3 days) Plus one or more of: ◦ ◦ ◦ ◦ Evanescent rash Generalized lymphadenopathy Hepatosplenomegaly Serositis Arthritis EXCLUSION OF OTHER DIAGNOSES Poor indicators Polyarticular onset and course Rheumatoid factor positive girls Systemic disease with persistent features Delay in starting effective treatment Good indicators Oligoarticular disease Goals ◦ Disease remission ◦ Symptomatic improvement ◦ ◦ ◦ ◦ Stiffness Pain Joint range of movement Prevent joint damage Normal growth and development Education and normal adolesence Prevent eye damage from Uveitis Multidisciplinary team ◦ Paediatric rheumatologist ◦ Nurse specialist ◦ Occupational Therapist ◦ Physiotherapist ◦ Social worker ◦ Ophthalmologist ◦ Podiatrist Anti inflammatory drugs ◦ NSAIDs ◦ Glucocorticoids “Disease modifying drugs” ◦ Methotrexate ◦ Etanercept ◦ New biologic agents for recalcitrant disease Avascular necrosis of the femoral head usually 2-10 (peak 4-6) yrs. 3-5 boys:girls Bilateral 30 % Imaging: Asymmetry in femoral heads Consider MRI or Nuclear medicine if clinical suspicion is high 10-13 years old Overweight boys 25% bilateral within 18/12 Slip of femoral head through growth plate (posteriorly and inferiorly) Imaging: AP and (frog) lateral films needed CT/ MRI in cases of difficulty Klein line should intersect femoral head Inappropriate history Physical signs don’t match story Other concerning features Concerns raised by others Chondromalacia patella Adolescent girls Painful knees - kneeling - going up stairs Osgood-Schlatter disease Adolescent boys Pain and swelling at tibial tuberosity Increased by exercise Osgood-Schlatter disease Adolescent boys Pain and swelling at tibial tuberosity Increased by exercise Tenderness +/- swelling of tibial tuberosity Pain on resisted extension of knee Clinical diagnosis DO NOT XRAY Very common May be generalised or localised Frequently responsible for musculoskeletal pain Common cause of lower limb pain If symptomatic – correct with good footware and insoles 25-40% of children! 3-5 years and 8-12 years Typical history Wake during night with pain Eased with massage May be worse after active day No daytime symptoms No abnormal physical signs No identifiable inflammatory or mechanical condition Chronic pain Impact on daily activities Average age 9 – 12 years Girls > boys Disease of the developed world CFS/ME Fibromyalgia Diffuse idiopathic pain Localised idiopathic pain eg RSD History History History Examination Examination Examination Investigations: targeted Blood Count ◦ ? Appropriate to clinical features Inflammatory markers ◦ Usually mirror clinical features ◦ Not always raised in inflammatory conditions Blood and synovial fluid cultures ANA/Rh Factor ◦ Not helpful in making a diagnosis Imaging ◦ Need to use best modality and ask the right question Musculoskeletal complaints are common in childhood Serious pathology leads to long term disability if not appropriately managed Diagnosis is dependant on good history and examination