Chapter 17
Lecture
PowerPoint
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Hole’s Human Anatomy
and Physiology
Twelfth Edition
Shier w Butler w Lewis
Chapter
17
Urinary System
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2
17.1: Introduction
• A major part of homeostasis is maintaining the composition,
pH, and volume of body fluids within normal limits
• The urinary system removes metabolic wastes and
substances in excess, including foreign substances like drugs
and their metabolites that may be toxic
• It consists of a pair of kidneys, a pair of ureters, a urinary
bladder and a urethra
3
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Kidney
Renal
vein
Hilum
Renal
artery
Inferior
vena cava
Abdominal
aorta
Ureters
Urinary
bladder
Urethra
© CNRI/SPL/Photo Researchers, Inc.
4
17.2: Kidneys
• A kidney is a reddish brown, bean-shaped organ with a
smooth surface
• In the adult it is about 12 centimeters long, 6 centimeters
wide, and 3 centimeters thick
• It is enclosed in a tough, fibrous capsule
5
Location of the Kidneys
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Kidney
Adipose tissue
Parietal
peritoneum
Spleen
Aorta
Small intestine
Large intestine
Inferior vena cava
Pancreas
Stomach
(a)
Adrenal gland
Twelfth rib
Kidney
Renal fascia
Hip bone (cut)
Liver
Parietal peritoneum
Renal fascia
Large intestine
6
(b)
Kidney Structure
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Renal cortex
Renal medulla
Renal capsule
Renal corpuscle
Nephrons
Renal
cortex
Minor calyx
Major calyx
Renal sinus
Renal column
Fat
in renal sinus
Renal pelvis
Renal papilla
Collecting
duct
Renal
medulla Renal
tubule
Papilla
Minor calyx
(b)
(c)
Renal pyramid
Ureter
(a)
7
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Inferior vena cava
Abdominal aorta
Suprarenal artery
Suprarenal vein
Adrenal gland
Renal artery
Renal column
Renal capsule
Renal pelvis
Renal papilla
Renal vein
Renal medulla
Hilum
Renal pyramid
Renal cortex
Ureter
Minor calyx
8
Function of the Kidneys
• The main function of the kidneys is to regulate the volume,
composition, and pH of body fluids
• The kidneys remove metabolic wastes from the blood and
excrete them to the outside of the body, including nitrogenous
and sulfur-containing products of protein metabolism
• The kidneys also help control the rate of red blood cell
production, regulate blood pressure, and regulate calcium ion
absorption
9
Renal Blood Vessels
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Proximal
convoluted tubule
Cortical radiate
artery and vein
Arcuate vein
and artery
Interlobar
vein and artery
Renal artery
Cortex
Medulla
Efferent arteriole
Peritubular
capillary
Cortical radiate
artery and vein
Afferent arteriole
Distal convoluted
tubule
Renal vein
Renal pelvis
Ureter
(a)
(b)
10
b: © L.V. Bergman/The Bergman Collection
Renal Blood Vessels
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Efferent arteriole
Peritubular
capillary
(a) Afferent arteriole
Glomerulus
Renal tubules
Glomerulus
Glomerular
capsule
(b)
(a) : Tissues and Organs: A Text-Atlas of Scanning Electron Microscopy, by R.G. Kessel and R.H. Kardon. © 1979 W.H. Freeman and Company
(b) : Courtesy of R.B. Wilson MD, Eppeley Institute for Research in Cancer, University of Nebraska Medical Center
11
The Renal Corpuscle
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Afferent
arteriole
Blood
flow
Efferent
arteriole
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Slit pore Pedicel Primary process
of podocyte
Blood
flow
Glomerular
capsule
Parietal layer
of glomerular
capsule
Slit por
Glomerulus
Proximal
convoluted
tubule
Visceral layer of
glomerular capsule
Pedicel Primary process
of podocyte
© David M. Phillips/Visuals Unlimited
12
Nephrons
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Glomerular
capsule
Cortical radiate
artery
Proximal
convoluted
tubule
Afferent
arteriole
Distal convoluted
tubule
Glomerulus
Efferent
arteriole
Peritubular
capillary
Cortical radiate
vein
Renal
cortex
From renal
artery
To renal
vein
Nephron
loop
Descending
limb
Ascending
limb
Collecting
duct
Renal
medulla
13
Nephrons
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Collecting
ducts
Epithelial
cell
Blood
vessel
(a)
Renal
tubules
Glomerular
capsule
Glomerulus
Renal
corpuscle
(b)
14
a: © Biophoto Associates/Photo Researchers, Inc., b: © Manfred Kage/Peter Arnold
Juxtaglomerular Apparatus
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Glomerular
Afferent
capsule
arteriole
Glomerulus
Efferent
arteriole
Proximal
convoluted
tubule
Juxtaglomerular
apparatus
Distal
convoluted
tubule
Glomerulus
Podocyte
Afferent arteriole
Nephron loop
Juxtaglomerular
cells
Macula densa
(a)
Glomerular capsule
Efferent arteriole
(b)
Juxtaglomerular
apparatus
Ascending limb
of nephron loop
15
Cortical and Juxtamedullary Nephrons
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Cortical nephron
Renal
cortex
Juxtamedullary
nephron
Renal
medulla
Collecting
duct
16
Blood Supply of a Nephron
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Glomerular
capsule
Cortical radiate
artery and vein
Proximal
convoluted
tubule
Glomerulus
Efferent
arteriole
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Renal artery
Interlobar artery
Arcuate artery
Afferent arteriole
Distal
convoluted
tubule
Peritubular
capillaries
Cortical radiate artery
Afferent arteriole
Glomerular capillaries
Efferent arteriole
Vasa recta
Peritubular capillaries
Cortical radiate vein
Arcuate vein
Collecting duct
Interlobar vein
Nephron loop
Renal vein
17
17.3: Urine Formation
• The main function of the nephrons and collecting ducts is to
control the composition of body fluids and remove wastes
from the blood, the product being urine
• Urine contains wastes, excess water, and electrolytes
• Urine is the final product of the processes of:
• Glomerular filtration
• Tubular reabsorption
• Tubular secretion
18
Urine Formation
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Arteriole
Venule
Net reabsorption
Blood
flow
Net filtration
Interstitial fluid
(a) In most systemic capillaries, filtration predominates at the arteriolar end
and osmotic reabsorption predominates at the venular end.
Afferent
arteriole
Glomerular
capillaries
Peritubular
capillaries
Efferent
arteriole
Venule
Blood
flow
Glomerular
filtration
Filtered
fluid
Tubular
reabsorption
Tubular fluid
Tubular
secretion
Urine
Renal tubule
(b) In the kidneys, the glomerular capillaries are specialized for filtration. The renal tubule is
specialized to control movements of substances back into the blood of the peritubular
capillaries (tubular reabsorption) or from the blood into the renal tubule (tubular secretion).
19
Glomerular Filtration
• Glomerular filtration
• Substances move from the blood to the glomerular capsule
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Glomerulus
Proximal
convoluted
tubule
Afferent
arteriole
Capillary
endothelium
Podocyte
Glomerular
filtrate
Glomerular
capsule
Fenestrae
Blood
flow
Podocyte
Efferent
arteriole
20
(a)
(b)
Plasma, Glomerular Filtrate, and
Urine Components
21
Filtrate Pressure
• The main force that moves substances by filtration through
the glomerular capillary wall is hydrostatic pressure of the
blood inside
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Hydrostatic
pressure of
blood
Glomerular hydrostatic
pressure
Plasma colloid
osmotic pressure
Capsular
hydrostatic
pressure
Net Outward Pressure
Outward force, glomerular hydrostatic pressure =
Inward force of plasma colloid osmotic pressure =
Inward force of capsular hydrostatic pressure
=
Net filtration pressure
=
+60 mm
–32 mm
–18 mm
+10 mm
22
Filtrate Rate
• Glomerular filtration rate (GFR) is directly proportional to
the net filtration pressure
Net filtration pressure = force favoring filtration
(glomerular capillary
hydrostatic pressure)
–
forces opposing filtration
(capsular hydrostatic pressure
and glomerular capillary osmotic pressure)
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170
160
150
140
130
117
110
Liters
• Normally the glomerular net
filtration pressure is positive
causing filtration
• The forces responsible include
hydrostatic pressure and osmotic
pressure of plasma and the
hydrostatic pressure of the fluid
in the glomerular capsule
180 Liters
180
100
90
80
70
60
50
40
30
17
10
0.6 – 2.5 Liters
0
Urine
Glomerular filtrate
(a)
(b)
23
Control of Filtrate Rate
• GFR remains relatively constant through a process called
autoregulation
• Certain conditions override autoregulation, including when
GFR increases
• Primarily three mechanisms are responsible for keeping the
GFR constant:
• Autoregulation
• Increased sympathetic impulses that decrease GFR by
causing afferent arterioles to constrict
• The hormone-like renin-angiotensin system
• There also is the hormone atrial natriuretic peptide
(ANP) affects sodium causing an increase in GFR
24
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Lung capillaries
Kidney
Liver
Renin
Angiotensinogen
Angiotensinconverting
Enzyme (ACE)
Angiotensin I
Angiotensin II
Bloodstream
Release into
bloodstream
Stimulation
• Vasoconstriction
• Increased
aldosterone
secretion
• Increased
ADH secretion
• Increased thirst
25
Tubular Reabsorption
• Tubular reabsorption
• Substances move from the renal tubules into the
interstitial fluid where they then diffuse into the
peritubular capillaries
• The proximal convoluted tubule reabsorbs (70%):
• Glucose, water, urea, proteins, and creatine
• Amino, lactic, citric, and uric acids
• Phosphate, sulfate, calcium, potassium, and sodium
ions
26
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Blood
flow
Blood
flow
Afferent
arteriole
Glomerular
capsule
Efferent
arteriole
Glomerulus
Glomerular
filtrate
Afferent
arteriole
Glomerular
capsule
Efferent
arteriole
Glomerulus
Glomerular
filtrate
Peritubular
capillary
Tubular
reabsorption
Peritubular
capillary
Tubular
secretion
Renal
tubule
Renal
tubule
Blood flow
(a)
Blood flow
(b)
27
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Blood
flow
Glomerulus
Glomerular
capsule
Blood
flow
Glomerular
filtrate
Proximal
convoluted
tubule
Na+
Na+
Cl–
PO4–3
HCO3–
N+
Cl–
Na+
H2
O
H
2
O
Isotonic
tubular fluid
+
+
–
–
–
–
+
–+
–+
+–
–+
–+
–+
++
–+
+–
––
++
––
1 Sodium ions
are reabsorbed by
active transport
2 Negatively charged ions
are attracted to positively
charged ions
3 As concentration of ions
(solute) increases in plasma,
osmotic pressure increases
4 Water moves from proximal
tubule to capillary by
osmosis
Peritubular capillary
Blood
flow
28
29
Tubular Secretion
• Tubular secretion
• Substances move from the plasma of the peritubular
capillaries into the fluid of the renal tubules
• Active transport mechanisms function here
• Secretion of substances such as drugs and ions
30
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Peritubular capillary
Blood
flow
K+or H+
Tubular reabsorption
Na+
Na+
Na+
Na+
Na+
Na+
Tubular fluid
Tubular secretion
Na+
Na+
H+
K+
K+
K+
Na+
Na+
H+
Distal convoluted tubule
Na+
K+
Na+
Na+
Ascending limb
of nephron loop
Collecting duct
31
Regulation of Urine
Concentration and Volume
• Hormones such as aldosterone and ANP affect the solute concentration
of urine, particularly sodium
• The ability of the kidneys to maintain the internal environment rests in a
large part on their ability to concentrate urine by reabsorbing large
volumes of water
• The distal convoluted tubule and the collecting duct are impermeable to
water, so water may be excreted as dilute urine
• If ADH is present, these segments become permeable, and water is
reabsorbed by osmosis into the extremely hypertonic medullary interstitial
fluid
• A countercurrent mechanism in the nephron loops (the descending and
the ascending limbs) ensures that the medullary interstitial fluid becomes
hypertonic
• This mechanism is known as the countercurrent multiplier
• The vasa recta also contributes as a countercurrent mechanism
32
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Distal convoluted
tubule
Medullary
interstitial fluid
H2O
H2O
H2O
H2O
H2O
Hypertonic
interstitial
fluid
Collecting duct
Hypertonic
interstitial
fluid
H2O
Dilute urine
(a)
low ADH levels
Medullary
interstitial fluid
H2O
H2O
Collecting duct
Concentrated urine
(b)
high ADH levels
33
34
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1
H2O
Na+
Cl–
Salty
Increasing
NaCl
concentration
2
Cl–
Na+
Isotonic fluid
H2O
H2O
Descending
limb
(permeable
to water)
(a)
H2O
Cl–
Na+
Cl–
Na+
H2O
Hypotonic fluid
More
salty
Thick ascending
limb (impermeable
to water)
3
Medullary
interstitial
fluid
Hypertonic
fluid
Na+
Cl–
H2O
Na+
Cl–
Even
more
salty
(b)
35
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Blood
flow
Blood
flow
Increasing
NaCl
concentration
NaCl
NaCl
NaCl
NaCl
NaCl
NaCl
Medullary
interstitial
fluid
NaCl
NaCl
Vasa
recta
36
37
Urea and Uric Acid Excretion
• Urea:
• A by-product of amino acid catabolism
• The plasma concentration reflects the amount or protein
in diet
• It enters the renal tubules through glomerular filtration
• It contributes to the reabsorption of water from the
collecting duct
• About 80% is recycled
• Uric acid:
• Is a product of nucleic acid metabolism
• It enters the renal tubules through glomerular filtration
• Most reabsorption occurs by active transport
• About 10% is secreted and excreted
38
Urine Composition
• Urine composition reflects the volumes of water and solutes
that the kidneys must eliminate from the body or retain in the
internal environment to maintain homeostasis
• It varies from time to time due to dietary intake and physical
activity, but is:
• About 95% water
• Usually contains urea, uric acid, and creatinine
• May contain trace amounts of amino acids and varying
amounts of electrolytes
• Volume varies with fluid intake and environmental
factors
39
Renal Clearance
• This is the rate at which a chemical is removed from the
plasma
• It indicates kidney efficiency
• Tests of renal clearance:
• Inulin clearance test
• Creatinine clearance test
• Para-aminohippuric acid (PAH) test
• These tests of renal clearance are used to calculate the GFR
(glomerular filtration rate)
40
17.4: Elimination of Urine
• After forming along the nephrons, urine:
• Passes the collecting ducts to:
• Openings of the renal papillae:
• Enters the minor and major calyces:
• Passes through the renal pelvis:
• Enters into the ureters:
• Enters into the urinary bladder:
•The urethra carries the urine out of the body
41
Ureters
• The ureters:
• Each is about 25 centimeters long
• Extends downward posterior to the parietal peritoneum
• Runs parallel to vertebral column
• Join the urinary bladder in the pelvic cavity
• The wall of ureter has three layers:
• The inner mucous coat
• The middle muscular coat
• The outer fibrous coat
42
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Mucous coat
Lumen
Muscular coat
Fibrous coat
Adipose tissue
© Per H. Kjeldsen
43
Urinary Bladder
• The urinary bladder is a hollow, distensible, muscular organ
located within the pelvic cavity, posterior to the symphysis
pubis and inferior to the parietal peritoneum
• It contacts the anterior walls of the uterus and vagina in the
female, and lies posteriorly against the rectum in the male
• The openings for the ureters is the area of trigone
• It has four layers: inner mucous coat, a submucous coat, a
muscular coat, and an outer serous coat
• Smooth muscle fibers comprise the detrusor muscle which
is the muscle of the bladder wall
44
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Ureter
Abdominal wall
Parietal peritoneum
Urinary bladder
Symphysis pubis
Prostate gland
Urethra
Rectum
Rectum
(a)
(b)
45
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Serous coat
Ureter
Urinary bladder
Ureter
Detrusor
muscle
Submucous
coat
Ductus (vas)
deferens
Mucous coat
Openings of
the ureters
Seminal
vesicle
Trigone
Neck
Prostate gland
Internal urethral sphincter
Prostate gland
Urethra
Region of external
urethral sphincter
(a)
Urethra
(b)
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Muscular coat
Mucous coat
Submucous
coat
Lumen
© John D. Cunningham/Visuals Unlimited
47
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Ureter
Urinary
bladder
Trigone
Urethra
External
urethral orifice
(a)
Ureter
Trigone
Prostatic
urethra
Membranous
urethra
Penile
urethra
External
urethral orifice
(b)
Urinary
bladder
Prostate
gland
Bulbourethral
gland
Penis
48
Urethra
• The urethra is a tube that conveys urine from the urinary
bladder to the outside of the body
• Its wall is lined with a mucous membrane and it has a thick
layer of longitudinal smooth muscle fibers
• In a female:
• It is about 4 centimeters long
• It runs obliquely
• In a male:
• It is about 17.5 centimeters long
• It has a dual function for both urination and reproduction
• It has three sections:
• Prostatic urethra
• Membranous urethra
• Penile urethra
49
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Urethral glands
Muscle layer
Lumen of urethra
Mucous membrane
© Ed Reschke
50
Micturition
• Urine leaves the urinary bladder by micturition or urination
reflex
51
Micturition
52
17.5: Lifespan Changes
• The urinary system is sufficiently redundant, in both structure and
function, to mask age-related changes
• The kidneys become slower to remove nitrogenous wastes and toxins
and to compensate for changes that maintain homeostasis
• Changes include:
• The kidneys appear scarred and grainy
• Kidney cells die
• By age 80 the kidneys have lost a third of their mass
• Kidney shrinkage is due to loss of glomeruli
• Proteinuria may develop
• The renal tubules thicken
• It is harder for the kidneys to clear certain substances
• The bladder, ureters, and urethra lose elasticity
• The bladder holds less urine
53
Important Points in Chapter 17:
Outcomes to be Assessed
17.1: Introduction
 Name the organs of the urinary system and list their general functions.
17.2: Kidneys
 Describe the location of the kidneys.
 Describe the structure of a kidney.
 List the functions of the kidneys.
 Trace the pathway of blood flow through the major vessels within a kidney.
 Describe a nephron and explain the functions of its major parts.
17.3: Urine Formation
 Explain how glomerular filtrate is produced and describe its composition.
54
Important Points in Chapter 17:
Outcomes to be Assessed
 Explain how various factors affect the rate of glomerular filtration and
identify ways that this rate is regulated.
 Define tubular reabsorption and explain its role in urine formation.
 Identify the changes in the osmotic concentration of the glomerular
filtrate as it passes through the renal tubule.
 Identify the characteristics of the countercurrent mechanism and
explain its role in concentrating the urine.
 Define tubular secretion and explain its role in urine formation.
17.4: Elimination of Urine
 Describe the structures of the ureters, urinary bladder, and urethra.
 Define micturition and explain how it occurs and how it is controlled.
55
Important Points in Chapter 17:
Outcomes to be Assessed
17.5: Lifespan Changes
 Describe how the components of the urinary system change with age.
56