UMS Spring Semester 2014
Student ID………………………
Section no: ……………………..
Student name………………………………..
Section time…………………………………
Molecular genetics
First : Define the following
a) Molecular genetics is the
b)
Alkaptonuria is
c)
Molecular Definition of a Gene
2
d) Gene expression is
Chromosomes are
Total : 6
Second: compare between
Eukaryotic and prokaryotic Genes
prokaryotes
eukaryotes
6
What is the main genetic cause of the following
a) Phenylketonuria (PKU)
B) Albinism is
n
C) Lesch-Nyhan Syndrome is caused by
D) Sickle-cell anemia is the result of
c) Cystic Fibrosis (CF)
1
1
1
Ashgan Abougabal
Who discovers what
1
thought that DNA was 3 strands
find that Cytosine complements
Guanine
and
Adenine
complements
Thymine
genes make proteins
make genes from DNA
isolate the
enzyme
first
A
Linus
Pauling
Wilkins
B
C
Rosalind
Franklin
Edwin
Chargaff
D
1
Beadle
and
Edward
Hershey
and
Chase
restriction
Developed
automated
sequencing mechanism
demonstrated that pre-mRNA is
processed by the excision of
introns and exons
was the first to propose the Archibald
relationship between genes and
Garrod
proteins
the first to associate a specific
gene with a specific chromosome
Howard
Temin
and David
Baltimore
Leroy
Hood
Phillip
Sharp
and
Richard
Roberts
Thomas
Hunt
Morgan
Total: 10
Third : what do you know about
a)
Base composition
2
b) arginine synthesis pathway



2
Phenylketonuria (PKU)
Albinism is caused by
Ashgan Abougabal
a)
What are the main outcomes of Franklin and Wilkins X-ray crystallography experiments that help
Watson to come up with the double helix structure
2
a) What are the Two steps required for Gene expression
b) Is the gene, the basic unit of genetic structure? Discuss
Morgan experimen
Hypothetical Chromosomes
Mention the Two types of experiments led to Kornberg’s proposal of the nucleosome
model.
First,
Second,
Forth : mention the important early discoveries which led to proof that DNA is a
Total : 4
4
genetic material
Fifth : Complete the following
a) Miescher discovered DNA and named …………………………..
b) …………………. discovers genes on chromosomes are the discrete
units of heredity
c) Watson and Francis Crick proposed the …………………………. Model
based on two sources of information
d) Tatum formulated the ………………………………………………
e) The modern description of One Gene-One Enzyme Hypothesis is:
………………………………………..
f) The gene is the unit of genetic information that controls
……………………………………………..
g) The gene is the unit of genetic information that specifies the
synthesis ………………………………………….
h) ………………………………….. keeps one strand of the parental double helix
conserved in each of the daughter double helices
i) Genotype ………………………………………………………………
j) ………………………….. is the visible expression of the genotype
k) Mutant alleles are usually ………………………….e
l) Each chromosome has ………………………………. which carries the
code for a couple of thousand genes.
m) The complexes between eukaryotic DNA and proteins are called
Chromatin, which typically contains about twice as much protein as
DNA.
n) ……………………………….. proteins rich in basic amino acids (lysinerich and arginine-rich; positive charge
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4
Ashgan Abougabal
o) There are 5 major types of histones: ………………………………….
which are very similar among different types of eukaryotes.
p) …………………………………., is bound to the DNA as it enters and
exists each nucleosome core particle.
q) nucleosome core particles has shown that they contain
…………………………….
pairs
of
DNA
wrapped
……………………………….. times around a histone core consisting of
two molecules each of …………………………………..
r) darker bands are generally found ………………………………….. or on
the …………………………………….. chromosome,
s)
What is the function of the following
t) The histones are extremely abundant proteins in eukaryotic cells
and are
u) non-histone chromosomal proteins. There are more than a thousand
different types of these proteins, which
v) .
c) How could George Beadle and Edward Tatum demonstrate the relationship
between genes and enzymes through studing Neurospora crassa (bread mold)
d) What are the main activities performed by genes
Grand total
4
.
Ashgan Abougabal
UMS Spring Semester 2014
Fundamental of microeconomics ( Econ 260)
Section no: ……………………..
no
5
Name
Section time…………………………………
ID
Signature
Ashgan Abougabal
UMS Spring Semester 2014
Fundamental of microeconomics ( Econ 260)
Section no: ……………………..
no
6
Name
Section time…………………………………
ID
Signature
Ashgan Abougabal
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Ashgan Abougabal