BIO305 Developmental Biology
Instructor: Dave Champlin
Class meets: Tuesdays and Thursdays, 8:45AM -10:00AM
Prerequisite: BIO107
Attendance: Attendance is required. If you miss more than
about six classes you should let me know why.
Required Text: Principles of Development, 4rd Edition, 2010.
Lewis Wolpert, et al.
Instructor: Dr. David Champlin Office: 305B Science
Building, Portland
Email: champlin@maine.edu
Office Phone: 228-8349
Office Hours: My office hours will be Tuesdays and
Wednesdays, 12:00 - 2:00 PM, but you can make an
appointment to meet with me at just about any time. Here is
a link that can help you with that:
http://web1.uct.usm.maine.edu/~champlin/Advising/Calendar
W.htm
Web Resources:
A copy of this syllabus is available at:
http://media.usm.maine.edu/~champlin/courseW.htm
At this site are copies of the exams from the previous time this
course was taught. My goal will be to post the PowerPoint
presentations I use in lecture at this site also as well as a
recording of the lecture for one week.
The maximum number of points for the course is 520 as follows:
Each is described in more detail on our course web site:
http://media.usm.maine.edu/~champlin/courseW.htm
review paper worth 100 points
two short writing assignments each worth 20 points
two exams each worth 100 points
cumulative final worth 100 points
five quizzes each worth 20 points
five in-class assignments each worth 20 points
No make-ups for missed quizzes or in-class assignments, but you can drop
the lowest two scores of the ten total quizzes / assignments. Each quiz
will be announced at least a week ahead of time, but the in-class assignments
won’t be announced ahead of time.
Day
Date
Reading Topic
T
9/3
pp.216-231 (Ch. 6)
C. elegans, model systems, and molecular genetics
Watch three Audio/Video handouts: 1A), 1B), and 1C
Th
9/5
Ch. 1
An introduction to developmental biology
T
9/10 QUIZ 1 (covers A/V Handouts 1A, 1B, and 1C) More introduction
Watch two Audio/Video handouts: Review of transcription regulation, Parts 1 and 2
Th
9/12
Ch. 3
Vertebrate life cycles
T
9/17 QUIZ 2
(covers A/V Handouts 2A and 2B)
Vertebrate axes and germ layers
Th
9/19
CH. 4
Vertebrate axial patterning
T
9/24
More vertebrate body plan
Th
9/26
Ch. 5
Early patterning of vertebrate nervous systems
T
10/1
EXAM 1 Chapters 1, 3, 4, and pp216-231
Th
10/3
Ch. 2
Molecular development of Drosophila
T
10/8
More molecular development of Drosophila
Th
10/10
Ch. 7
Plant development
On Thursday, 10/10, Please bring a copy of the primary research article you have selected (or more
than one if you haven’t decided) plus your notes on the article.
What is developmental biology?
What is developmental biology?
Lewis Wolpert = author of our book
What is developmental biology?
"What is the one thing everyone should learn about science?"
Wolpert responded:
I would teach the world that science is the best way to understand
the world, and that for any set of observations, there is only one
correct explanation. Also, science is value-free, as it explains the
world as it is.
Lewis Wolpert = author of our book
What is developmental biology?
BIO407 Environmental Modulation of Developmental Mechanisms
Taught every other spring. It was taught last spring.
Textbook: Scott Gilbert. 2010. Ecological Developmental Biology:
Integrating Epigenetics, Medicine, and Evolution
What is developmental biology?
Maine Medical Center Research Institute
in Scarborough
Research internships
Summer fellowship program
What is developmental biology?
What is developmental biology?
What is developmental biology?
What is developmental biology?
You have made your way from worm to man, and
much within you is still worm.
Friedrich Nietzsche, 1883, from Also Sprach Zarathustra
Caenorhabditis elegans
C. elegans
Caenorhabditis elegans = C. elegans nematode
The 2002 Nobel Prize in Medicine was awarded to these
scientists for the use of C. elegans to understand
programmed cell death (PCD).
A fertilized nematode egg and early embryos
as viewed with Nomarski optics =
Differential Interference Contrast (DIC).
As each C. elegans worm grows
from the fertilized egg, it has
an invariant cell lineage.