Research and Training Programs
at the
National Institutes of Health
Richard A. Baird, Ph.D.
Director, Division of Interdisciplinary Training
National Institute of Biomedical Imaging
and Bioengineering
NSF Minority Faculty Development Workshop
July 30-August 2
National Institute of Biomedical Imaging and Bioengineering
The NIH Mission
NIH is the steward of
medical and behavioral
research for the Nation.
Its mission is science in the
pursuit of fundamental
knowledge about the nature
and behavior of living
systems and the application
of that knowledge to extend
healthy life and reduce the
burdens of illness and
disability.
An agency of the
Department of
Health and Human
Services, the NIH is
the Federal focal
point for health
research.
National Institute of Biomedical Imaging and Bioengineering
Nation
al Institutes of Health
Na
Office of the Director
National Institute
on Aging
National Institute
on Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
National Institute
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Eye
Institute
National Institute
of General
Medical Sciences
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing Research
National Institute of
Biomedical Imaging
and Bioengineering
National Center
for Complementary
and Alternative
Medicine
Fogarty
International
Center
National Center
for Research
Resources
National Library
of Medicine
National Center on
Minority Health and
Health Disparities
Clinical Center
Center for
Information
Technology
Center for
Scientific Review
National Institute of Biomedical Imaging and Bioengineering
A Simple View of the NIH
Grants
Managment
IR
Extramural
Scientific
Review
Research
Scientific
Program
National Institute of Biomedical Imaging and Bioengineering
FY 2005 NIH Budget
$28.59 Billion
Res. Man. &
Support
All Other
Research Project
Grants 53%
$15.3 billion
Intramural
Research
R&D Contracts
Training 3%
$761 million
Other Research 8%
$2.0 billion
Research
Centers
National Institute of Biomedical Imaging and Bioengineering
NIH Peer Review Process
My Application
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PI / Institution submits application
Center for Scientific
Review
Study Section
Evaluates Scientific Merit
Revision / Resubmission
Institute or Center
Evaluates Relevance
Conduct
Research
Advisory Council
$$$
$$$
Recommends Action
Institute Director
Allocates Funds
National Institute of Biomedical Imaging and Bioengineering
What Happens to My Grant?
(Why Does it Take so Long?)
Receipt
all applications initially land at the same loading dock
Referral
Assignment to a standing study section
Based on specific review or referral guidelines
Can take up to 1 month
Initial Review
5-6 months after receipt
Council Review
7-8 months after receipt
Award
10 or more months after receipt
National Institute of Biomedical Imaging and Bioengineering
Who Do I Call at NIH?
Before Submission
Program Staff: scientific interest, scope, initial approval
Grants Management Staff: administrative and budget issues
Submission and Review
Review Staff: receipt, referral, and review
 After Review
Program Staff: likelihood of funding
After Award
Grants Management Staff: administrative and budget issues
Program Staff: research progress
National Institute of Biomedical Imaging and Bioengineering
Types of NIH Announcements
PA = Program Announcement
– PAR = PA w/ Special Review
– PAS = PA w/ Set Aside Funds
RFA = Request for Applications
–Special Review
–Set Aside Funds
National Institute of Biomedical Imaging and Bioengineering
NIH Research Funding
 Solicited (Targeted) Applications
Applications in response to specific Program
Announcements (PA) or Requests for
Applications (RFA).
 Unsolicited (Investigator-initiated) Applications
The vast majority of NIH applications are
unsolicited (investigator-initiated).
National Institute of Biomedical Imaging and Bioengineering
Grant Mechanisms
R = Research
T = Training (Institutional)
F = Fellowship (Individual)
K = Career Development
National Institute of Biomedical Imaging and Bioengineering
Research Grant Mechanisms
R01
– Basic NIH research grant, extensive preliminary data
– Renewable, supports supplements and amendments
– Average award = $300k / year for 4-5 years
R21
– Exploratory/Developmental grant, little or no preliminary data
– Non-renewable, supports supplements and amendments
– Average award = $275k / year for 2 years
R03
– Small Research Grant, little or no preliminary data
– Non-renewable, does not support supplements or amendments
– Average award = $50k / year for 2 years
Application Receipt Dates: February 1, June 1, October 1
National Institute of Biomedical Imaging and Bioengineering
Training and Fellowship Awards
Training and Fellowship awards provide support to
predoctoral students while they work toward their research
degrees or to postdoctoral fellows while they obtain
additional research experience in a mentor’s laboratory.
 T32 – Institutional Training Grants
Application Receipt Dates: Jan 10, May 10, September 10
 F31 – Kirschstein Individual Predoctoral Fellowships
 F32 – Kirschstein Individual Postdoctoral Fellowships
 F33 – Individual Senior Fellowships
Application Receipt Dates: April 5, August 5, December 5
National Institute of Biomedical Imaging and Bioengineering
Career Development Awards
Career Development awards provide mentored support for
investigators who have completed their postdoctoral
training and are changing fields or need protected time for
research during critical periods of their careers.
 K01 – Research Scientist Development Award
 K08 – Clinical Scientist Development Award
 K23 – Patient-Oriented Development Award
 K24 – Mid-career Patient-oriented Development Award
 K25 – Quantitative Scientist Development Award
Application Receipt Dates: February 1, June 1, October 1
National Institute of Biomedical Imaging and Bioengineering
Training Grants and Fellowships
Predoctoral
Fellowships (F31)
Institutional
Training Grants (T32)
Senior Fellowships
Postdoctoral
(F33)
Fellowships (F32)
College
Graduate School
Postdoctoral
Career Transition Award
(K99/R00)
Independent
Investigator
Mentored Quantitative
Scientist Award (K25)
Mentored Research Scientist
Award (K01)
Career Development Awards
National Institute of Biomedical Imaging and Bioengineering
Clinical Training Grants and Fellowships
Institutional
Training Grants (T32)
Postdoctoral
Senior Fellowships
(F33)
Fellowships (F32)
Medical
School
Internship/Residency
Fellowship
Independent
Investigator
Midcareer Investigator
in Patient-Oriented
Research (K24)
Mentored Clinical Scientist
Mentored Patient-Oriented
Development Award (K08)
Research Career Dev. Award (K23)
Career Development Awards
National Institute of Biomedical Imaging and Bioengineering
NIBIB Mission
To improve human health by
leading the development and
accelerating the application of
biomedical technologies.
The Institute is committed to
integrating the physical,
engineering, and computer
sciences with the life sciences to
advance basic research and
medical care.
National Institute of Biomedical Imaging and Bioengineering
How is NIBIB Different from
Other NIH Institutes?
 Supports design-driven and needs-driven research in
addition to hypothesis-driven research.
 Promotes discovery, development, and clinical translation of
emerging or existing technologies.
 Supports technologies with broad application to multiple
biological processes, diseases, and organ systems.
 Promotes interdisciplinary training and career development
at interface between biological and physical sciences.
National Institute of Biomedical Imaging and Bioengineering
NIBIB Mission Areas
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Imaging Agents & Molecular Probes
Image Displays
Image Guided Therapies & Interventions
Image Perception
Image Processing
Magnetic, Biomagnetic & Bioelectric Devices
Magnetic Resonance Imaging & Spectroscopy
Nuclear Medicine
Optical Imaging & Spectroscopy
Ultrasound and Acoustics
X ray, Electron & Ion Beam
National Institute of Biomedical Imaging and Bioengineering
NIBIB Mission Areas
•
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Biosensors
Biomaterials
Biomechanics
Biomedical Informatics
Computational Biology
Drug & Gene Delivery Systems
Lab-on-a-chip Technologies
Medical Devices & Implant Science
Nanotechnology
Rehabilitation Engineering
Surgical Tools & Techniques
Telemedicine
Tissue Engineering
National Institute of Biomedical Imaging and Bioengineering
Interdisciplinary Training
Biological, clinical, and
physical scientists speak
different languages.
Biologists and clinicians
may not know what is
technically possible;
engineers may not know
the biomedical problems.
Interdisciplinary mentoring
and training is essential to
insure successful research
collaborations.
National Institute of Biomedical Imaging and Bioengineering
NIBIB Training Priorities
 Feeding the Pipeline
 Transitioning to Independence
 Developing Clinician-Researchers
 Training at the Interface
 Increasing Diversity
National Institute of Biomedical Imaging and Bioengineering
Feeding the Pipeline
 NIBIB/NSF Bioengineering and Bioinformatics
Summer Institutes (BBSI): attracts undergraduate
and graduate quantitative science majors to
biomedical careers.
 Biomedical Engineering Summer Internship Program
(BESIP): provides undergraduate bioengineering
students the opportunity to participate in cutting-edge
research at NIH laboratories.
 NIH/NIST Joint Postdoctoral Program: provides serial
postgraduate research experiences in the biological
and physical sciences at NIH and NIST.
National Institute of Biomedical Imaging and Bioengineering
Transitioning to Independence
Research Independence is Ocurring at Ever-later Age
Average Age of R01/R23/R29 Awardees by Terminal Degree
44
45
44
42
M.D.-Ph.D.
42
41
M.D.
40
40
Ph.D.
39
38
38
37
37
36
35
1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003
Fiscal Year
National Institute of Biomedical Imaging and Bioengineering
Average age
43
Pathway to Independence Program
(also known as K99/R00 or K22 Award)
-US citizens OR non-citizens at US institutions
-First applications (April 7, 2006, Oct 1/Feb 1/June 1)
-First awards (Fall, 2007)(NIH ~175 awards/NIBIB ~5 awards)
-Five (5) years of total support
Phase I - 1-2 yrs mentored postdoctoral support
($90K total cost including 8% F&A)
Phase II – 3 yrs independent research support contingent
upon securing an independent research position and
administrative review ($175K/yr direct with full F&A)
-In-house review
-Application Receipt Dates: February 1, June 1, October 1
National Institute of Biomedical Imaging and Bioengineering
NIBIB Outreach and Recruitment
 Grantsmanship Workshops
National Bioimaging and Bioengineering Meetings
Professional Bioimaging and Bioengineering Societies
NIBIB Regional Grantsmanship Workshops
-Fall, 2005 - George Washington University
-Spring, 2006 - North Carolina Biotechnology Center
-Fall, 2006 - Houston, TX
 NIBIB New Investigator Policy
Funds new investigators within 5% of the R01 payline.
Improves success rate of new investigators.
Applies only to unsolicited applications.
National Institute of Biomedical Imaging and Bioengineering
Developing Clinician-Researchers
 Medical Students
Dedicated Medical Student Training Slots
 Medical Residents
Residency Supplement Program
Loan Repayment Program
 Clinical Fellows
Mentored (K08) and Patient-oriented (K23,K24)
Career Development Programs
National Institute of Biomedical Imaging and Bioengineering
Training at the Interface
 Attract Quantitative Scientists to Biomedicine
HHMI-NIBIB Interface Partnership
K25 Career Development Program
BBSI, BESIP, NIBIB-NIST training programs
 Interface Basic and Clinical Researchers
NIH Blueprint for Neuroscience Initiative
NIH Roadmap Initiatives
NIBIB Institutional Training Programs for
Co-mentoring Basic and Clinical Researchers
National Institute of Biomedical Imaging and Bioengineering
HHMI-NIBIB Interface Initiative
Phase I (November, 2005): 3 years of HHMI funds to establish
and develop interdisciplinary training programs at 10 institutions.
Phase II (FY2008-2010): 5 years of NIBIB funds for student
support to sustain training programs during their early years.
NJIT/Rutgers/
NJMS
JHU
Brandeis
CMU
UCI
UCSF
UCSD
UChicago
Computational Biology
Imaging Informatics
Systems Biology
Nanotechnology
Neuroscience
UNM
CMU
UPenn
National Institute of Biomedical Imaging and Bioengineering
Increasing Diversity
 Predoctoral Fellowships
-Minority Students
-Students With Disabilities
 Diversity Supplements
-Underrepresented Racial and Ethnic groups;
-Individuals with Disabilities; and
-People from Culturally, Economically, Educationally, or
Socially Disadvantaged Backgrounds.
 Part-time and Full-time Reentry Supplements
-Women (or men) who have interrupted research careers for
child care or to attend to other family responsibilities
National Institute of Biomedical Imaging and Bioengineering